Transcription activator-like effector nucleases (TALENs) are a type of gene editing technology that can be used to introduce specific changes into the DNA of living cells. TALENs are made by fusing a DNA-binding domain from a transcription activator-like effector (TALE) protein to a nuclease domain, an enzyme that can cut DNA. When a TALEN binds to a specific DNA sequence, the nuclease domain is activated and cuts the DNA at that location.
TALENs can be applied to help protect plants from the effects of climate change. TALENS have been used to improve the quality of products derived from crops.
This resource page provides news and research articles on TALENs published in Biotech Updates, as well as blogs, infographics, and publications developed by ISAAA, in partnership with The 2Blades Foundation.
- TALENs for Better Antidiabetic Plants (April 10, 2024)
- Silkworms Engineered for Super Silk (March 27, 2024)
- Updates on Gene Editing Tomato with TALENs (March 13, 2024)
- Developing Better Cereal Crops with TALENs (January 24, 2024)
- New Tool Predicts TALEN Binding Sites Accurately (January 17, 2024)
- MitoTALENs Restore Fertility of Ogura Cytoplasmic Male Sterile Broccoli (January 17, 2024)
- 2Blades Licenses TALEN Technology for Organelle Editing (November 15, 2023)
- Plant Mitochondrial Gene Editing Using TALENs (October 11, 2023)
- Experts Use TALENs and Agrobacterium to Improve Potatoes (September 27, 2023)
- Experts Release Updates on TALEN Construction Systems (August 30, 2023)
- New Technique to Pinpoint Off-Target Effects in Gene Editing (August 23, 2023)
- Enhanced Gene Editing in Ciona with CRISPR-Cas9 and TALENs (August 9, 2023)
- APEC Economies Tackle Regulatory and Policy Solutions for Agri-biotech (August 2, 2023)
- Experts Provide Recommendations for Regulation of Medicinal Products Based on Gene Editing (June 14, 2023)
- Gene Editing Strategies for Reducing Phytic Acid in Crops (June 14, 2023)
- Scientists Create Gene-edited Allergen-free Chicken Eggs (May 24, 2023)
- Scientists Use TALENs to Edit Tuna (December 9, 2021)
- New Book on Genome Editing Tools and Gene Drives (September 30, 2021)
- Researchers Present Prospects for Genome Editing of Potato (August 18, 2021)
- Japanese Researchers Develop New Gene-Editing Tool to Create Non-GM Crops (July 7, 2021)
- Customizable Molecular Scissors for Tailoring Plant Genomes (July 1, 2021)
- TALENs and Other Molecular Tools to Help Prevent the Next Plant Pandemic (May 19, 2021)
- Researchers Explore Off-target Effects of TALEN-mediated Bar-knockout in Rice (May 5, 2021)
- New ISAAA Infographic Illustrates TALENs (March 10, 2021)
- MitoTALENs Enable More Understanding of Plant Mitochondrial Genomes (February 24, 2021)
- TALEN Beats CRISPR-Cas9 in Editing Tightly-packed DNA (February 3, 2021)
- Researchers Report a Simple and Efficient TALE Using Twin Primer Assembly (January 27, 2021)
- Improving Biotic Tolerance in Crop Plants through Gene Editing (January 20, 2021)
- Breakthroughs in Science Using TALENs (January 13, 2021)
- What are TALENs? (January 6, 2021)
- TALENs Used for Multiple Gene Knockout in Chrysanthemum (November 4, 2020)
- Researchers Engineer a Rapid TALEN Assembly Protocol for Genome Editing (September 30, 2020)
- New Bicistronic TALENs Enhance Genome Editing (September 9, 2020)
- CRISPR Dominates Genome Editing Market, TALENs Projected to Grow until 2025 (August 12, 2020)
- TALENs Used to Edit Mitochondrial DNA (July 22, 2020)
- ISAAA Launches Open-access Resources on Genome Editing (July 22, 2020)
- Scientists Use TALENs for Targeted Genome Editing of Potato (July 8, 2020)
- USDA Classifies Gene-Edited Soybean As Non-Regulated (June 10, 2020)
- North America Genome Editing Market Projected to Increase by 2025 (May 15, 2019)
- Screening for CRISPR and TALENs Edits, Better with Ribonucleoproteins (November 28, 2018)
- Researchers Update on Potato Genome Editing (November 14, 2018)
- CRISPR-Cas9 Used to Retain Function of Mutated Growth Gene in Tomato (October 24, 2018)
- Gene-Edited High-Fiber Wheat Could Hit the Market by 2020 (October 17, 2018)
- Scientists Update on CRISPR Utility for Crop Improvement (August 22, 2018)
- Researchers Test TALEN Genome Editing on Peanut (May 23, 2018)
- NDC80 Protein Complex Responsible for Cell Division in Arabidopsis (April 18, 2018)
- TALENs-mediated Editing in Potato via Agroinfiltration (February 14, 2018)
- CRISPR-Cas9 and TALENs Used to Generate Mutants for Studying Small RNA in Legumes (December 6, 2017)
- Genome Editing in Potato using TALENs Delivered via Agroinfiltration (October 11, 2017)
- TALEN-Mediated Mutagenesis of Large Number of COMT Copies in Sugarcane (September 27, 2017)
- Evaluation of HvPAPhy_a Gene in Barley Using CRISPR-Cas9 and TALENs (August 9, 2017)
- Researchers Review Genome Editing Techniques for Nitrogen Fixation Research in Legumes (June 28, 2017)
- Development of Gene-Specific Rice Mutants via AvrXa23-based TALENs (June 7, 2017)
- TALEN-Mediated Knock-in Genome Editing in Silkworm (May 17, 2017)
- Review of the Impacts of Genome Editing Techniques in Plants (April 12, 2017)
- DNA Methylation Affects the Efficiency of TALEN-mediated Genome Editing in Rice (March 29, 2017)
- Researchers Review Targeted Genome Editing Techniques in Horticultural Crops (February 15, 2017)
- Development of Gene-Specific Rice Mutants via AvrXa23-based TALENs (February 8, 2017)
- Programming Antiviral Defenses in Plants through Genome Editing (February 1, 2017)
- TALEN-mediated Mutagenesis of COMT in Sugarcane Improves Cell Wall Decomposition for Ethanol Production (November 9, 2016)
- Non-bruising GE Potato Cleared for Sale by USDA (November 3, 2016)
- TALENs-mediated Targeted DNA Insertion Approach for Potato (October 12, 2016)
- Scientists Review the Use of Engineered Viruses in Genome Editing Tools (October 12, 2016)
- Geminivirus-Mediated Genome Editing in Potato Using Sequence-Specific Nucleases (September 14, 2016)
- Improved Cold Storage Traits of Potato through Targeted Gene Knockout (April 8, 2015)
- Informing the Filipino Youth About Gene Editing Applications in Animals (March 6, 2024)
- Biotech Innovations for a Sustainable Agriculture (November 15, 2023)
- Can We Edit the Future of Food? (August 2, 2023)
- How Can TALENs Help Feed the World by 2050? (December 14, 2022)
- ISAAA Inc. Builds Repository of Genome Editing Information (April 20, 2022)
- ISAAA Features Latest Genome Editing Innovations in Biweekly News Release (March 9, 2022)
- ISAAA Successfully Launches Primer on New Breeding Innovations (December 15, 2021)
- ISAAA and Partners to Launch Genome Editing Primer (December 9, 2021)
- TALENs and CRISPR: Next Generation Plant Breeding Innovations (March 31, 2021)
- What You Need to Know About TALENs (March 24, 2021)
- First Commercialized Gene-edited Plant Developed Using TALENs (January 13, 2021)
- New Pocket K on TALENs Published (December 22, 2020)
- ISAAA Brief 56-2021: Breaking Barriers with Breeding: A Primer on New Breeding Innovations for Food Security
- Pocket K No. 59: Plant Breeding Innovation: TALENs (Transcription Activator-Like Effector Nucleases)
- Double Helix Vol.2 No.1
- Points to Ponder on Gene Editing: Can We Edit the Future of Food?
- Biotech sQuizBox: All About Gene Editing
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