TALENs Used to Edit Mitochondrial DNAJuly 22, 2020
An inter-university team of scientists developed a method to successfully edit the mitochondrial DNA within living cells in a precise manner by combining the features of CRISPR with TALENs.
The scientists found an interbacterial toxin that enabled them to change a cytosine base in the DNA code to thiamine, thereby harnessing the potential to correct some point of mutations in the mitochondrial genome. This was further enhanced by delivering an editor that negated its toxicity and pairing it with a protein guide TALE that is able to cross the mitochondrial membrane. This resulted in the precise point mutations in the mitochondrial DNA.
The newly discovered approach may eventually become a tool that scientists can use to better model mitochondrial diseases, as mitochondrial genome editors have the potential to help treat mitochondrial-derived diseases.
You might also like:
- Scientists Use TALENs for Targeted Genome Editing of Potato
- New Methods Promise to Speed Up Development of New Plant Varieties
- Scientists Finally Record Successful Mitochondrial DNA Editing in Plants
The Crop Biotech Update is a weekly newsletter of ISAAA, a non-for-profit organization. The CBU is distributed for free to over 23,000 subscribers worldwide to inform them about the key developments in biosciences, especially in agricultural biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
- Structural Analysis of COVID-19 Spike Protein Describes its Evolution
- Researchers Identify Possible Immune Targets in SARS-CoV-2 Genome
- Human Trials Begin for COVID-19 Plant-Based Technology Vaccine
News from Around the World
- GM Crops' Impact Creates a Halo Effect, Expert Explains
- ISAAA Launches Open-access Resources on Genome Editing
- Oat Genome Now on ARS Website
- Most Accurate Map of Pig Genome Gives Insights to Breeding Healthier Animals
- Researchers Develop Fine-tune Methods for Gene Silencing
Plant Breeding Innovations
- Scientists Use CRISPR-Cas9 for Single-nucleotide Editing in Rice
- TALENs Used to Edit Mitochondrial DNA
- Experts Review Methods Used to Minimize Off-Target Effects in Genome Editing
- Researchers Turn to CRISPR Genome Editing to Make Cyanide-Free Cassava
Subscribe to CBU: