Programming Antiviral Defenses in Plants through Genome EditingFebruary 1, 2017
Studies on plant–virus interactions have increased our understanding of plant resistance mechanisms, thus, providing new tools for crop improvement. For the past decades, RNA interference, a post-transcriptional gene silencing approach, has been used to induce antiviral defenses in plants with the help of genetic engineering technologies.
New genome editing systems (GES) have revolutionized the development of virus resistance in plants. The most famous GES are zinc finger nucleases (ZFN), transcription activator-like effector nucleases (TALEN), and clustered regularly interspaced short palindromic repeats/Cas9 endonuclease (CRISPR/Cas9). These introduce mutations, which can "turn off" genes, via double-strand breaks at specific DNA sequences via non-homologous recombination end-joining.
However, recent studies of GES targeting ssRNA molecules, including virus genomes, paved the way for future studies on developing plant defense against RNA viruses. Most of the pathogenic plant virus species have an RNA genome and at least 784 species have positive ssRNA. In their study, Gustavo Romay and Claude Bragard provide a summary of the latest progress in plant antiviral defenses mediated by GES.
They also discuss some current regulatory framework for agricultural products involving the use of such engineering technologies.
For more on this study, read the article in Frontiers in Microbiology.
The Crop Biotech Update is a weekly newsletter of ISAAA, a not-for-profit organization. The CBU is distributed for free to over 23,000 subscribers worldwide to inform them about the key developments in biosciences, especially in agricultural biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
News from Around the World
- Uganda MP Wants Constituents to be First Beneficiaries of GM Crops
- AATF Establishes First Early Generation Seed Production Entity in Sub-Saharan Africa
- Research Discovers How Plants "Turn Off" Immune Response after Confronting Pathogens
- University of Florida Research Team Discovers Genetic Key to Restoring Tomato Flavor
- International Collaboration to Discover Sources of Genetic Resistance to Corn Diseases
- Study Shows Effects of Soil Salinity on Cry1Ac Expression in Bt Cotton
- Seed-specific Overexpression of BASS2 Enhances Oil Production in Arabidopsis Seeds
Plant Breeding Innovations
- Programming Antiviral Defenses in Plants through Genome Editing
- Researchers Use CRISPR/Cas9 for Precise Excision of Transgenes from Rice Genome
Beyond Crop Biotech
- Genomes of Two Human Malaria Species Revealed
- Scientists Develop New System that Use Mobile Phone to Treat Disease
- 4th Conference of Cereal Biotechnology and Breeding
- ISAAA in 2016
- The National Academies Releases Book on GE Crop Study
- Video: Hawaii GMO Papaya Real Solutions Real Lives
Read the latest:
- Crop Biotech Update (October 5, 2022)
- Genome Editing Supplement (October 5, 2022)
- Gene Drive Supplement (September 28, 2022)
Subscribe to CBU: