Scientists Review the Use of Engineered Viruses in Genome Editing Tools
October 12, 2016| |
Genome editing based on sequence-specific designer nucleases modify genetic information of living cells in a targeted manner. Delivering these designer nucleases, individually or together with donor DNA templates, can result in gene knock-outs or knock-ins.
Viral vectors, which are engineered replication-defective viruses, recently gained an important role as delivery vehicles for donor DNA templates and designer nucleases, such as zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and clustered, regularly interspaced, short palindromic repeats-associated Cas9 (CRISPR−Cas9).
Researchers from Leiden University Medical Center in the Netherlands reviewed the use of engineered viral particles on genome editing and also focused on their main scaffolds. They discussed the repurposing of viral vectors as delivery systems for genome editing tools as well as information on their characteristics, and the advantages and disadvantages of this new approach.
For more information, read the article in Molecular Therapy.
| |
Biotech Updates is a weekly newsletter of ISAAA, a not-for-profit organization. It is distributed for free to over 22,000 subscribers worldwide to inform them about the key developments in biosciences, especially in biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
-
See more articles:
-
News from Around the World
- Nobel Prize for Chemistry Awarded to Molecular Machine Makers
- Tanzania Plants First GM Maize Field Trial
- Ethiopian Government Commended for Agri-biotech Initiatives
- First Harvest of Arctic® Golden Apples Completed
- American Soybean Growers Urge US House, Senate to Support Biotech Education Funding
- Chinese Scientists Control Verticillium dahliae Wilt Using Gene Technology
-
Research Highlights
- Expression of Phytase Gene in Wheat Endosperm Increases Availability of Iron and Zinc
- Transcription Factor ERF109 Improves Salt Tolerance in Arabidopsis
- Overexpression of AtOxR Improves Abiotic Stress Tolerance and Vitamin C Content in Arabidopsis
-
Beyond Crop Biotech
- Protective Protein of Water Bears Helps Human DNA Withstand X-ray Damage
- Beer Yeast Genomes Reveal Domestication History
-
From the BICs
- ACSAD and EBIC Hold Biotech Workshop and Form Arab Biotech Network
-
Announcements
- ICABBBE 2017
-
Plant
- TALENs-mediated Targeted DNA Insertion Approach for Potato
- Scientists Review the Use of Engineered Viruses in Genome Editing Tools
-
Read the latest: - Biotech Updates (December 4, 2024)
- Gene Editing Supplement (November 27, 2024)
- Gene Drive Supplement (February 22, 2023)
-
Subscribe to BU: - Share
- Tweet