Gene-Edited Animals for Agricultural Applications Database
This ISAAA database compiles a list of animals developed through gene editing (also called New Breeding Techniques) for agricultural applications. The information provided in this database is based on the following scientific report:
Van Eenennaam, AL. 2023. New Genomic Techniques (NGT) in animals and their agri/food/feed products. ESFA Supporting Publications, Vol. 20 (Issue 9). https://doi.org/10.2903/sp.efsa.2023.EN-8311.
This database is managed in collaboration with the University of California - Davis, USA
Historically, genetically engineered organisms must be granted regulatory approval for genetically modified organisms (GMOs) to be commercialized or sold in any given country. A database of GM crop events approved worldwide is maintained on the ISAAA website.
Gene-edited products are often not considered for regulatory approval, as many countries and jurisdictions are considering edits that could have been achieved using conventional breeding (e.g., knockouts, intraspecies allele substitutions) as conventional breeding. Most of the gene-edited products do not have to go through a GMO approval process but rather enter into a regulatory process to obtain a determination as to whether they are or are not a GMO. Depending upon the country, this is sometimes based on the Cartagena protocol definition of a living modified organism (LMO) which includes "any living organism that possesses a novel combination of genetic material obtained through the use of modern biotechnology." This is often interpreted to mean they are free of any "transgene" or "foreign" DNA.
What does undergone regulatory process mean?
Developers of several gene-edited animals have entered a regulatory process in different countries to obtain a determination as to whether they will be regulated as a GMO. This process goes by various names e.g., "prior consolation" in Argentina where all gene-edited products must be submitted on a case-to-case basis to the Argentine Biosafety Commission (CONABIA). CONABIA must respond within 60 days to whether a new product will be subject to GMO regulations (Whelan and Lema, 2016). Products that have gone through this process and received a determination that permits their commercialization in that country are listed as "YES" for having gone through a regulatory process, and products from those gene-edited animals can be sold in that country.
A determination does not necessarily mean products are currently in the marketplace but rather indicates they could be sold there if a developer chooses to do so. Links to the regulatory documents, based on publicly available English (or translatable) decision documents of each approving country, are included where available.
For more information on the regulation of animal biotechnologies please see the following review:
Hallerman, E., Bredlau, J., Camargo, L.S.A. et al. 2024. Enabling regulatory policy globally will promote realization of the potential of animal biotechnology. CABI Agric Biosci 5, 25 https://doi.org/10.1186/s43170-024-00221-6
Entries found: 192
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- Atlantic Salmon (Salmo salar)
- Blunt snout sea bream (Megalobrama amblycephala)
- Cattle (Bos taurus)
- Cattle (Bos taurus x Bos taurus indicus)
- Channel catfish (Ictalurus punctatus)
- Chicken (Gallus gallus)
- Common Carp (Cyprinus carpio)
- Duck (Anas platyrhyncos)
- Farmed Carp (Labeo rohita)
- Gibel carp (Carassius gibelio Bloch)
- Goat (Capra hircus)
- Honeybee (Apis mellifera)
- Loach (Paramisgurnus dabryanus)
- Nile tilapia (Oreochromis niloticus)
- Olive flounder (Paralichthys olivaceus)
- Oyster (Crassostrea gigas)
- Pig (Sus scrofa domesticus)
- Quail (Coturnix japonica)
- Rabbit (Oryctolagus cuniculus)
- Rainbow trout (Oncorhynchus mykiss)
- Red sea bream (Pagrus major)
- Redhead cichlid (Vieja melanura)
- Royal farlowella (Sturisoma panamense)
- Sheep (Ovis aries)
- Silkworm (Bombyx mori)
- Southern Catfish (Silurus meridionalis)
- Sterlet (Acipenser ruthenus)
- Tiger pufferfish (Takifugu rubripes)
- White crucian carp (Carassius auratus civieri)
- Yellow catfish (Pelteobagrus fulvidraco)
- Yellow catfish (Tachysurus fulvidraco)
- Δ5fads2
- Δ6fads2-a
- Δ6fads2-b
- Δ6fads2-c
- AANAT (aralkylamine N-acetyltransferase)
- aldh1a2 (Aldehyde dehydrogenase family 1 member A2)
- alligator cathelicidin
- AMH (anti-Mullerian hormone)
- amhΔ-y
- AMHR2 (anti-Müllerian hormone receptor type 2)
- amhy (Y-localised anti-Müllerian hormone)
- ANPEP (alanyl aminopeptidase)
- ASIP (agouti signaling protein)
- ASIP 1 (Agouti Signaling Protein)
- ASIP 2 (Agouti-signaling protein)
- ASMT (acetylserotonin O-methyltransferase)
- BCO2 (beta-carotene oxygenase 2)
- BLG (β-Lactoglobulin)
- BmNPV (Bombyx mori nuclear polyhedrosis virus)
- bmp2 (Bone morphogenetic protein 2)
- BMPR1B (Bone morphogenetic protein receptor type-1B)
- CD163 (Cluster of Differentiation 163)
- CD18 (Cluster of Differentiation 18)
- CD1D
- CD46 (Cluster of Differentiation 46)
- Cgfoxl2a-B
- Cgfoxl2b-A
- Cgfoxl2b-B
- chNHE1 (chicken Na+/H+ exchanger type 1)
- CMAH (Cytidine monophosphate-N-acetylneuraminic acid hydroxylase)
- Cyp11c1 (cytochrome P450, family 11, subfamily c, polypeptide 1)
- cyp26a1 (cytochrome P450, family 26, subfamily A, polypeptide 1)
- DAZL (Deleted In Azoospermia Like)
- DDX3Y (DEAD-Box Helicase 3 Y-Linked)
- DDX4 (DEAD-Box Helicase 4)
- dmrt6 (doublesex and mab-3-related transcription factor 6)
- dnd (dead end)
- dnd1 (Dead end protein homolog 1)
- eEF1A1b (eukaryotic translation elongation factor 1 alpha 1b)
- Eif2s3y (eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked)
- elongase
- elovl2
- esr1 (Estrogen receptor 1)
- esr2a (estrogen receptor 2a)
- esr2b (estrogen receptor 2b)
- fat-1 (Omega-3 fatty acid desaturase fat-1)
- FBXO40 (F-Box Protein 40)
- FGF5 (Fibroblast Growth Factor 5)
- foxh1 (forkhead box H1)
- fsh (Follicle-stimulating hormone)
- FST (Follistatin)
- G0S2 (G0/G1 Switch 2)
- GDF9 (Growth Differentiation Factor 9)
- GFP (Green Fluorescent Protein)
- GGTA1 (α-1,3-galactosyltransferase)
- gsdf (Gonadal soma-derived factor)
- IARS (Isoleucyl-tRNA synthetase)
- ICP4 (immediate early infected-cell polypeptide-4)
- IGF1 (Insulin Like Growth Factor 1)
- IGF2 (Insulin-like growth factor 2)
- IGF3 (insulin-like growth factor 3)
- KISS1 (KiSS-1 Metastasis Suppressor)
- LacS (Sulfolobus solfataricus β-glycosidase)
- LEPR (Leptin receptor)
- let-7 (lethal-7)
- LF (Lactoferrin)
- LH (luteinizing hormone)
- lysostaphin
- MaSp1 (major ampullate spidroin-1)
- MC1R (Melanocortin 1 Receptor)
- mKast (middle-type Kenyon cell-preferential arrestin-related gene-1)
- MLPH (melanophilin)
- Mrjp1 (royalactin)
- MSTN (Myostatin)
- Myomaker
- NANOS2 (Nanos C2HC-Type Zinc Finger 2)
- NANOS3 (Nanos C2HC-Type Zinc Finger 3)
- NRAMP1 (Natural resistance-associated macrophage protein-1)
- ntl (no tail)
- NUP155 (nucleoporin 155)
- opg (osteoprotegerin)
- OTX2 (Orthodenticle Homeobox 2)
- OVA (ovalbumin)
- OVM (ovomucoid)
- pAPN
- PCBP1 (Poly (rC)-binding protein 1)
- PDX1 (Pancreatic And Duodenal Homeobox 1)
- pfpdz1
- piwil2 (Piwi Like RNA-Mediated Gene Silencing 2)
- PMEL (premelanosomal protein)
- Pmel17 (pre-melanosomal protein)
- pmela (premelanosome protein a)
- pmelb (premelanosome protein b)
- polled
- PPARγ (Peroxisome proliferator-activated receptor gamma)
- PRLR (Prolactin Receptor)
- PRNP (prion protein)
- PrP (prion protein)
- pRSAD2
- RBL (rhamnose binding lectin)
- RELA
- rln3a (relaxin 3a)
- rln3b (relaxin 3b)
- RSPO1 (R-spondin 1)
- runx2 (runt-related transcription factor 2)
- Sf-1 (Steroidogenic factor-1)
- shRNAs (antiviral small hairpin RNAs (shRNAs) at ROSA locus)
- Site directed integration for null-segregant technology
- slc45a2 (solute carrier family 45 member 2)
- SOCS2 (suppressor of cytokine signaling 2)
- SP110 (Mouse SP110)
- sp7 (sp7 transcription factor)
- spp1 (secreted phosphoprotein 1)
- SRY (Sex Determining Region Y)
- Tβ4 (Thymosin beta 4)
- TICAM1 (TIR Domain Containing Adaptor Molecule 1)
- TLR22 (Toll-like receptor 22)
- Tsp1a (Thrombospondin 1 )
- Tva
- twist
- TYR (Tyrosinase)
- UCP1 (Uncoupling protein 1)
- wt1a
- wt1b
- ZFY (Zinc Finger Protein Y-Linked)
- Acceligen Inc.
- AgResearch Ltd
- Agricultural Technology Research Institute
- Agricultural University, Nanchang
- Auburn University
- Beijing Key Laboratory for Animal Genetic Improvement, China Agricultural University
- Biological Sciences Section, Central Research Institute for Feed and Livestock
- Central Institute of Freshwater Aquaculture
- China Agricultural University
- Chinese Academy of Agricultural Sciences
- Chinese Academy of Sciences, Beijing
- Chinese Academy of Sciences, Shanghai
- Chinese Academy of Sciences, Wuhan
- College of Animal Science and Technology, Northwest A&F University
- College of Animal Science and Technology, Yunnan Agricultural University
- College of Life Science and Technology, Xinjiang University
- College of Life Sciences, Shihezi University
- College of Veterinary Medicine, Northwest A&F University
- CSIRO Health and Biosecurity, Australian Centre for Disease Preparedness
- Czech Academy of Sciences
- Department of Animal Sciences, The Ohio State University
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo
- Department of Marine Biosciences, Tokyo University of Marine Science and Technology
- Department of Surgery, Indiana University School of Medicine
- Depatment of Bio Life Science, ShinGu University
- Division of Organ Transplantation, Department of Surgery, Osaka University Graduate School of Medicine
- Ernst Federal Science Center for Animal Husbandry
- Faculty of Bioscience and Bioindustry, Tokushima University
- Friedrich-Loeffler-Institut
- Genus PLC
- Guangdong Ocean University
- Hendrix Genetics Research & Technology Services (Hendrix Genetics RTS)
- Hiroshima University
- Huazhong Agricultural University
- Hunan Normal University
- Inner Mongolia University
- Institut Pasteur de Montevideo
- Institute of Agrobiological Sciences, NARO
- Institute of Animal Sciences, Chinese Academy of Agricultural Sciences
- Institute of Marine Research
- Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis/College of animal science and technology, Yangzhou University
- Jiangsu Livestock Embryo Engineering Laboratory, Nanjing Agricultural University
- Jiangsu Provincial Engineering Research Center for Precision Animal Breeding
- Jilin University, Changchun
- Ministry of Agriculture (MOA), Key Laboratory of Animal Biotechnology
- Ministry of education & Key Lab of Swine Genetics
- MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University
- Nanjing Agricultural University
- National Institute of Advanced Industrial Science and Technology
- National Institute of Fisheries Science
- Northwest A&F University
- Norwegian University of Science and Technology, Department of Biology
- Optipharm Inc
- Recombinetics
- Regional Fish Institute, Ltd.
- School of Agriculture, Meiji University
- School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University
- School of Medical Engineering, Foshan University,
- Seoul National University, Gwanak-gu
- Seoul National University, Pyeongchang-gun
- Shandong Provincial Maternal and Child Health Care Hospital, Jinan, China and Department of Biological Sciences, National University of Singapore
- Shanghai Fisheries Institute
- Shanghai Jiaotong University
- Shanghai Ocean University
- Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University
- Soochow University
- South China Agricultural University, Guangzhou, China; Wens Foodstuff Group Co., Ltd.
- Southwest University
- State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University
- State Key Laboratory of Stem Cell and Reproductive Biology, Chinese Academy of Sciences
- Sun Yat-sen University
- Technical University Munich
- The Roslin Institute, University of Edinburgh
- Tokushima University
- University of California, Davis
- University of China
- University of Chinese Academy of Sciences
- University of Edinburgh
- University of Edinburgh (Roslin Institute) with Genus
- University of Maryland
- University of Missouri
- University of South Bohemia in Ceske Budejovice
- University of Stirling
- University of Washington
- US Meat Animal Research Center, United States Department of Agriculture (USDA)
- Volcani Institute
- Washington State University
- Yanbian University
- Yangzhou University
- Yat-sen University
- Yunnan Agricultural University