New Plant Engineering Method to Help Mass Production of Malaria DrugJune 15, 2016
A new research reports that a novel and inexpensive technique for producing artemisinin, the main ingredient in the most effective treatment for malaria, could help meet global demands for the drug. Artemisinin is produced in low yields by the herb known as sweet wormwood, Artemisia annua.
Researchers from the Max Planck Institute of Molecular Plant Physiology have discovered a new way to produce artemisinic acid, the molecule from which artemisinin is derived, in high yields. Their method involves transferring its metabolic pathway from A. annua into tobacco, a high-biomass crop.
The team calls this approach COSTREL, short for combinatorial supertransformation of transplastomic recipient lines. The first step was to transfer the genes of the artemisinic acid pathway's core set of enzymes into the chloroplast genome of tobacco plants, generating what are known as transplastomic plants. The team then used their best transplastomic tobacco plant line to introduce an additional set of genes into its nuclear genome, generating the COSTREL lines. These remaining genes encode factors that increase the synthesis, or generation, of the acid in ways that are still largely unknown.
Read more about this research at the Max Planck Institute of Molecular Plant Physiology website.
The Crop Biotech Update is a weekly newsletter of ISAAA, a non-for-profit organization. The CBU is distributed for free to over 23,000 subscribers worldwide to inform them about the key developments in biosciences, especially in agricultural biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
News from Around the World
- Final Analysis Shows 100% Compliance of Parties to Kyoto Protocol
- G20 Ministers: Innovation in Agriculture the Key to Ending Extreme Hunger
- IWGSC Releases Wheat Sequence Repository for Wheat Researchers
- Study Reveals Experts' Attitudes towards Governance of Gene Editing
- ICRA: Pricing Controls and Compulsory Licensing of Bt Cotton Cloud the Long-term Growth of GM Seeds Industry
- Research Findings Bring Promise of Tailored Products for the Industry
- New Plant Engineering Method to Help Mass Production of Malaria Drug
- MfPIP2-7 Gene from Falcate Confers Cold Tolerance in Transgenic Tobacco
- Overexpression of Wheat Gene Improves Abiotic Stress Tolerance in Stiff Brome
Beyond Crop Biotech
- Plant-based Vaccine a Front Runner for New Polio Jab
- Scientists Use CRISPR to Grow Human Pancreas in Pigs
From the BICs
- ISAAA Report Launched in Kenya
- Postgraduate Course in Biosafety in Plant Biotechnology
- What are CRISPR/Cas9 and other New Breeding Technologies (NBTs)?
- The Necessary "GMO" Denialism and Scientific Consensus
Subscribe to CBU: