Biotech Updates

Prospects of Cellulosome Research for Processing of Waste Cellulose Residues

August 10, 2007
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VRV-4NK4739-3&_user=677719&_coverDate=06%2F30%2F&_rdoc=12&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%236244%232007%23999819996%23660562%23FLA%23display%23Volume)&_cdi=6244&_sort=d&_docanchor=&_ct=19&_acct=C000036823&_version=1&_urlVersion=0&_userid=677719
&md5=927ddad834625740cbd164dade406075

(Abstract access in the above website is possible, but full paper access requires subscription)

“Cellulose ethanol” or ethanol derived from processing of cellulosic plant biomass is thought to be the “way of the future” for ethanol-based biofuels. Naturally occurring cellulosic material from plant biomass is characterized as being “heterogeneous” and “recalcitrant”. In contrast, pure cellulose is homogeneous (consisting of glucose components) and can easily be converted to glucose (the raw material for ethanol fermentation) by the enzyme cellulase. These are the characteristics of plant biomass which present a bottleneck for the conversion into sugars for “cellulose ethanol” production. While pure cellulose can be easily degraded to simple sugars, the degradation of lignocellulosic plant biomass is not very effective. The use of a “multienzyme complex” or “cellulosome” is considered a more effective alternative. An article recently published in the journal Current Opinion of Biotechnology (URL above) presents some prospects of harnessing cellulosomes for cellulose waste management. Related Links for Information on Cellulosomes http://www.weizmann.ac.il/Biology/open_day/book/Abstracts/Ed_Bayer.pdf http://en.wikipedia.org/wiki/Cellulosomes  .