New Genome Editing Tool Designed to Make Big DNA EditsOctober 21, 2020
A new tool for cutting large chunks of DNA out of a cell's genome has been developed by experts from the University of California, San Francisco. The new system, dubbed as CRISPR-Cas3, is reported in Nature Methods.
"Cas3 is like Cas9 with a motor—after finding its specific DNA target, it runs on DNA and chews it up like a Pac-Man," said Joseph Bondy-Denomy, one of the authors of the study.
Compared to the popular CRISPR-Cas9 system, the new system uses a different bacterial immune system. As indicated in its name, the key enzyme is Cas3, which acts as a molecular wood chipper and is deleting longer stretches of DNA rapidly and accurately. The capability to delete or replace long stretches of DNA allows scientists to more efficiently evaluate the importance of genomic regions that has DNA sequences with undefined functions.
You might also like:
- Plant Breeding Innovation: CRISPR-Cas9 (Pocket K No. 54)
- Gene Editing Used to Develop Vitamin A-fortified Rice
- CRISPR Helps Determine Sorghum's Ability to Hide from Plant Pest
The Crop Biotech Update is a weekly newsletter of ISAAA, a not-for-profit organization. The CBU is distributed for free to over 23,000 subscribers worldwide to inform them about the key developments in biosciences, especially in agricultural biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
- International Team of Scientists Identify Common Vulnerabilities in COVID-19 and Other Lethal Coronaviruses
- COVID-19 Virus Can Survive 28 Days on Surfaces
News from Around the World
- WHO Refers to GM Mosquitoes as Beneficial Technology
- Scientists Use Glowing Venus Flytraps to Understand Its Closure Mechanism
- Pamela Ronald is 2020 World Agriculture Prize Laureate
- Pinkglow™, Del Monte's Pink Pineapple Now Available
- Indian Farmer Confirms Socio-economic Impact of Bt Cotton
- Biotech Experts to Tackle Global Impact of GM Crops
- EFSA Study Concludes Maize MON810 Poses No Risk to Humans, Animals, or the Environment
- Researchers Pinpoint Peanut Genes Linked to Salt and Drought Tolerance
Plant Breeding Innovations
- New Tool to Accelerate Crop Improvement with CRISPR
- New Genome Editing Tool Designed to Make Big DNA Edits
Read the latest:
- Crop Biotech Update (January 25, 2023)
- Genome Editing Supplement (January 18, 2023)
- Gene Drive Supplement (January 25, 2023)
Subscribe to CBU: