Soybean Cotyledon Used as Platform for Production of Therapeutic Proteins
March 20, 2019| |
The bone morphogenetic protein BMP2 has an important function in the production and regeneration of bone and cartilage, which is vital in maintaining skeletal integrity and bone fracture repair. Thus, BMP2 is commercially produced for clinical use. Researchers from Embrapa Recursos Genéticos e Biotecnologia, Brazil, and partners attempted to express human BMP2 in two plant systems, the lettuce chloroplast and soybean seeds.
The researchers introduced the rhBMP2 gene in two locations of the lettuce chloroplast genome. Analysis showed that BMP2 gene was transcribed but did not accumulate in the leaves.
On the other hand, two soybean events successfully expressed hBMP2 in the transgenic seeds. The recombinant BMP2 protein was administered to C2C12 cell cultures, which induced an osteogenic cascade as manifested in the improved expression of SP7 (osterix) and ALPI (alkaline phosphatase) genes.
The findings suggest that soybeans can be used to produce functional therapeutic proteins like BMP2.
Read more results in Transgenic Research.
| |
Biotech Updates is a weekly newsletter of ISAAA, a not-for-profit organization. It is distributed for free to over 22,000 subscribers worldwide to inform them about the key developments in biosciences, especially in biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
-
See more articles:
-
News from Around the World
- Production of Transgenic Plants Increased as Expected, Study Shows
- Genome Editing Offers Great Prospects for South Africa
- Strong Sales Figures Indicate Demand for GM Non-browning Apple
- Australian OGTR Invites Comments on GM Chickpea Field Trial
- USDA FAS-GAIN Evaluates China's 2018 Ag-biotech Industry
- Global Team of Experts Reinventing Sugarcane for More Applications
- Scientists Release Most Complete Genome Assemblies of Cotton
- Experts in Japan Conclude Gene-Edited Foods are Safe
- Biologists Explain Genetic Origins of Saffron Crocus
-
Research Highlights
- Nicotiana benthamiana as Suitable System for Expression of Cotton Boll Weevil α-amylase Inhibitor
- Soybean Cotyledon Used as Platform for Production of Therapeutic Proteins
-
Beyond Crop Biotech
- Modern Beer Yeast Emerged from Mix of European Grape Wine, Asian Rice Wine Yeast
-
Resources
- GMO Fun Facts: What is GMO in Full?
-
Plant
- UC Berkeley Physicist Reports a New High Precision Method for Genetic Engineering and Gene Editing
- Scientists Discover One-Step Genome Editing Technique that Accelerates Seed Breeding
-
Read the latest: - Biotech Updates (April 10, 2024)
- Gene Editing Supplement (April 10, 2024)
- Gene Drive Supplement (February 22, 2023)
-
Subscribe to BU: - Share
- Tweet