Genome Editing to Control Gene Expression in PlantsAugust 29, 2018
Scientist Huawei Zhang and colleagues from the State Key Laboratory of Plant Cell and Chromosome Engineering in China use genome editing to control the expression of four genes involved in the development or antioxidant biosynthesis in plants. The team targeted uORFs of these genes using a single-guide RNA to produce multiple types of mutations.
After uORF editing, they observed varying amounts of proteins from the targeted genes. They particularly noted that editing the uORF of LsGGP2, a gene encoding a key enzyme in lettuce vitamin C biosynthesis, resulted to increased oxidation stress tolerance and increased ascorbate content. The study emphasized the usefulness of gene editing in the discovery of biological mechanisms and improvement of crops.
For more information, access the full text in Nature Biotechnology.
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