CRISPR Gene-Editing Technology, Better with Cas12a
August 8, 2018| |
Cas9 is the first enzyme used in the CRISPR gene-editing technology. As if the tool could not get any better, researchers from The University of Texas at Austin found that Cas12a, which is more popularly known as Cpf1, is more precise in targeting genes for modification than Cas9.
Through quantitative kinetics, the team determined the specific gene-targeting mechanism of CRISPR-Cas12a. Results showed that Cas12a works like a "velcro" in the system, whereas Cas9 works like a "super glue." Thus, reversibility is possible with Cas12a, consequently reducing off-targets.
For more information, read the articles in UT News and Molecular Cell.
| |
Biotech Updates is a weekly newsletter of ISAAA, a not-for-profit organization. It is distributed for free to over 22,000 subscribers worldwide to inform them about the key developments in biosciences, especially in biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
-
See more articles:
-
News from Around the World
- The Need for GM Wheat
- New Multiple Gene Stacking Technique Could Develop Crops with Higher Yields and Better Traits
- Regulatory and Policy Officials of APEC Economies Briefed on Biotechnology and Plant Breeding Innovations
- Key Gene for Sugarcane Growth Has Been Identified
- Researches Report Protein that Controls Flowering thru Combined on and off Switches
- U.S. Dept of Interior Ends Ban on GE Crops and Neonicotinoid Pesticides in Refuge
- New Genome of Chinese Soybean Now Available
- Scientists Narrate Past, Present, and Future of the Bt Eggplant Project in Bangladesh
- European Commission Authorizes Five GM Crops
- Poland Releases Draft GE Labeling Legislation
-
Research Highlights
- Rice OsRACK1A Gene Negatively Regulates Salt Tolerance
- TaWRKY2-Overexpression Enhances Drought Tolerance in Wheat
-
Beyond Crop Biotech
- SCI+POP, A New Social Media Project in Canada
- Study Shows Poplar Trees Can Be Genetically Engineered Not to Spread
-
Plant
- Researchers Edit Yield-Increasing Genes in Rice
- Regulator of Symbiotic Nodulation in Lotus Found
- Study Reveals the Role of Malate Transporters in Rice Grain Yield
- CRISPR Gene-Editing Technology, Better with Cas12a
-
Read the latest: - Biotech Updates (April 17, 2024)
- Gene Editing Supplement (April 10, 2024)
- Gene Drive Supplement (February 22, 2023)
-
Subscribe to BU: - Share
- Tweet