Biotech Updates

Identification of Candidate Genes for Calanolide Synthesis in Santa Maria Tree

August 24, 2016

Santa Maria (Calophyllum brasiliense) is an important source of calanolides, which inhibit the reverse transcriptase of human immunodeficiency virus type 1. Despite its great medicinal importance, enzymes involved in calanolide as well as its biosynthetic pathway are still unknown.

Hilda-Beatriz Gómez-Robledo from Universidad Anáhuac in Mexico and colleagues analyzed the transcriptome of C. brasiliense leaves, stem, and roots. Using the transcriptome dataset as well as the structures of the calanolides, the team proposed several biosynthetic pathways to study. Finally, candidate genes in the dataset potentially involved in the calanolide biosynthetic pathway were recorded.

The data generated in this study could serve as an important basis for further molecular studies of C. brasiliense, especially for functional analysis of candidate genes involved in biosynthetic pathway of calanolides.

For more information on this study, read the full article in BMC Plant Biology.