IU Biologists Elucidates How Protein Machine Systems Tweak Gene Expression
March 2, 2012| |
Indiana University scientist led by Craig Pikaard have discovered that specific types of RNA polymerase enzymes, the molecular machines that convert DNA into RNA, can have a difference in roles depending on the variation in the protein subunits.
Multisubunit RNA polymerase IV and V (Pol IV and PolV) evolved as specialized forms of Pol II that control the RNA-directed DNA methylation and gene silencing in plants and other eukaryotes. The ninth subunit of Pol II and Pol V are the ones responsible for the difference in functions. The team conducted genetic and molecular tests and found out that a defect in the methylation process could be caused by impairment in PolV function.
Read the research article at http://www.cell.com/cell-reports/abstract/S2211-1247(12)00040-X and the media release at http://newsinfo.iu.edu/news/page/normal/21461.html?emailID=21461.
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