Expression of Recombinant Human Growth Hormone in GE Soybean Seeds
November 19, 2010| |
Human growth hormone (hGH), known as somatotropin, plays an important role in the cell cycle and growth. Production of hGH in normal humans decays after 20 years of age, and insufficiency or absence of the hormone in children and teenagers can cause hypo-pituitary dwarfism. Nicolau Cunha of Embrapa Genetic Resources and Biotechnology and colleagues produced hGH in genetically engineered soybean seeds. They utilized a subunit in the tissue-specific promoter from soybean and signal peptide from Coix lacryma-jobi, a tropical Asian grass to come up with the hGH-producing soybean seeds.
Results showed that 2.9% of the total soluble seed protein content of the transgenic seeds is bioactive hGH which are contained in the protein storage vacuoles. The protein sequence of hGH was further confirmed using mass spectrometry characterization. Thus, genetic engineering of soybean seeds to direct recombinant proteins could be a possible option in commercial production of biopharmaceuticals for humans.
Subscribers of Transgenic Research journal can access the research paper at http://www.springerlink.com/content/164tu24563072228/fulltext.html.
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