Scientists Determine Structure of Cas13d, a CRISPR Enzyme for RNA Editing
September 26, 2018| |
In the study, the researchers use cryo-electron microscopy to investigate the structure and activities of Cas13d. They froze the enzyme and captured its structure singly, with the guide RNA, and with the guide and target RNAs. Results revealed implication of various conformation on RNA targeting and recognition. The study is a major aid in designing strategies for transcriptomic engineering in the future.
For more information, read the article in Cell.
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