Researchers Develop Plant-produced Vaccine Candidates Against Bluetongue VirusJuly 26, 2017
Bluetongue is a disease of ruminants caused by bluetongue virus serotypes (BTV), which have caused serious outbreaks worldwide. Commercially, vaccines are available but there are risks. Recombinant vaccines are preferable to minimize the risks associated with these vaccines.
The team of Albertha R. van Zyl from the University of Cape Town in South Africa developed two novel protein body (PB) plant-produced vaccines Zera®-VP2ep and Zera®-VP2. Zera®-VP2ep contained sequences of multiple BTV serotypes and Zera®-VP2 contained the full-length BTV-8 VP2 codon-optimized sequence. Zera®-VP2ep was aimed at stimulating immune response to several BTV serotypes.
Both vaccines were successfully made in tobacco (Nicotiana benthamiana) via Agrobacterium-mediated expression. Analysis showed that the expressed proteins accumulated within the cytoplasm of plant cells. Preliminary immunogenicity studies showed that the vaccine candidates elicited anti-VP2 immune responses in mice.
These results demonstrate that the candidate vaccines have the potential as BTV vaccines and development of vaccines through plant platforms should be further investigated.
For more information, read the article in BMC Biotechnology.
The Crop Biotech Update is a weekly newsletter of ISAAA, a non-for-profit organization. The CBU is distributed for free to over 23,000 subscribers worldwide to inform them about the key developments in biosciences, especially in agricultural biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
News from Around the World
- Web Portal Established to Speed up Genetic Research in Plants
- India's B.R. Barwale Passes Away
- African Biosafety Regulators Embrace Biosafety Communication at ABBC 2017
- Biotechnology Praised at the Biggest Agri Expo in Uganda
- Adoption of GE Crops in the US
- New Gene in Corn Confers Resistance to Multiple Diseases
- Study Finds Plants Reprogram Their Genetic Material to Fight Pathogens
- China Gives Import Approval for Corn Rootworm Resistant Trait
- Russia Drafts Regulations for GE Feed
- Overexpression of BoC3H Gene Enhances Salt Stress Tolerance in Broccoli
- Study on the Effect of Light and Temperature on CBF14 Expression in Wheat and Barley
Plant Breeding Innovations
- CRISPR-Cas9 and CRISPR-Cpf1 Mediated Genome Editing of EPFL9 Gene in Rice
- Discovery on How CRISPR Proteins Identify Targets
Beyond Crop Biotech
- NAS Announces Awards for Science Communication
- Researchers Develop Plant-produced Vaccine Candidates Against Bluetongue Virus
Subscribe to CBU: