First Results from Human COVID-19 Immunology Study Identify Universally Effective AntibodiesJune 3, 2020
The first set of results from an immunological study of 149 people who have recovered from COVID-19 show that although the amount of antibodies they generated varies widely, most of them generated at least some that were intrinsically capable of neutralizing the SARS-CoV-2 virus. Three distinct antibodies that were shown to be the most potent in neutralizing SARS-CoV-2 have been found.
For over 5 weeks since April 1, 149 people who had recovered from COVID-19 visited The Rockefeller Hospital to donate plasma, the portion of the blood that contains the antibodies, and the immune B-cells that produce them. Scientists tested the neutralizing activity of the plasma samples and found the majority showed poor to modest neutralizing activity, but for 1 percent of donors, it was remarkably high.
Those "elite" responders are crucial as the high numbers of neutralizing antibodies in their serum makes it possible for researchers to catch the rare B cells that make them. Out of the numerous antibodies generated by elite responders who had the best performing plasma, the team identified 40 that neutralized the virus and zeroed in on three that could do so even at very low concentrations. The team has cloned these most potent antibodies and is now working to develop them for clinical use.
For more details, read the science news in The Rockefeller University website.
You might also like:
- First Human Trial of COVID-19 Vaccine Found Safe and Induces Rapid Immune Response
- Medicago Announces Positive Results of Trials for its COVID-19 Vaccine Candidate
- Researchers Discover Antibody that Blocks SARS-CoV-2 Infection in Cells
Biotech Updates is a weekly newsletter of ISAAA, a not-for-profit organization. It is distributed for free to over 22,000 subscribers worldwide to inform them about the key developments in biosciences, especially in biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
News from Around the World
- Zambia to Release 2 Drought Tolerant Cowpea Varieties
- Genome Editing and Its Applications in Health and Agriculture
- Chile Serves as a Key Enabler for Global Plant Breeding Innovations
- Omega-3 Canola Oil to Help Reduce Overfishing
- Bt Brinjal Farmers Earned 21.7% More, Satisfied with Yield and Crop Quality
- Plant Science Discovery Uncovers Ways to Improve Immune Responses
- Iranian GM Rice Found to Contribute to Environmental Health
- GA20ox-2 Targeted Mutation Produces Semi-dwarf Rice
- Scientists Find Potential Targets for COVID-19 Vaccine
- First Results from Human COVID-19 Immunology Study Identify Universally Effective Antibodies
Read the latest:
- Biotech Updates (September 20, 2023)
- Gene Editing Supplement (September 13, 2023)
- Gene Drive Supplement (February 22, 2023)
Subscribe to BU: