Chinese Scientists Test CRISPR Gene-editing in Human for the First TimeNovember 23, 2016
Scientists from Sichuan University in Chengdu, China conducted the very first human injection of gene-edited cells using CRISPR-Cas9 technique. The modified cells were injected into a patient with aggressive lung cancer at the West China Hospital in Chengdu.
According to the report published in Nature, immune cells from the patient's blood were harvested and then the specific genes were disabled using CRISPR-Cas9, which combines a DNA-cutting enzyme with a molecular guide that can be programmed to tell the enzyme precisely where to cut. The disabled gene codes for the protein PD-1, which normally puts the brakes on a cell's immune response: cancers take advantage of that function to proliferate. Then the researchers cultured the edited cells, multiplied them, and injected them back into the patient. They hope that without PD-1, the edited cells will attack and defeat the cancer. The research team plans to inject a total of 10 patients, who will be initially monitored for six months for any adverse effects. They will be continuously monitored for the succeeding months to see if they are benefiting from the treatment.
Read more in Nature.
Biotech Updates is a weekly newsletter of ISAAA, a not-for-profit organization. It is distributed for free to over 22,000 subscribers worldwide to inform them about the key developments in biosciences, especially in biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
News from Around the World
- Report Says Developing World Achieves Significant Growth in Biotechnology
- ICAR-CIRCOT Hosts High Level African Delegation Biotech Study Tour in India
- African Delegation Visits Indian Bt Cotton Farmers
- Scientists Shut off Plant's Sunshield to Boost Productivity
- U.S. Court Rejects GMO Ban in Hawaii County
- NZ Scientists Develop GE Ryegrass for Healthier Animals
- PH Highlights Role of Biotech in National Development
- Genome Sequence of 5,310-Year-Old Maize Cob Provides Insights on Its Early Domestication
- OsACOS12 is Vital in Pollen Exine Formation and Anther Development in Rice
- Overexpression of RAG2 Improves Grain Yield and Quality of Rice
Beyond Crop Biotech
- Chinese Scientists Test CRISPR Gene-editing in Human for the First Time
- DBT Prepares India for "Brucella-Free Villages"
From the BICs
- Filipino Senior High School Students Undertake Agri-biotech Boot Camp
- Inactivation of Symbiotic Nitrogen Fixation Related Genes in Lotus Using CRISPR-Cas9
- Researchers Engineer Potyvirus Resistance in Arabidopsis Using CRISPR/Cas9
Read the latest:
- Biotech Updates (May 31, 2023)
- Gene Editing Supplement (May 31, 2023)
- Gene Drive Supplement (February 22, 2023)
Subscribe to BU: