New Gene Editing Technology Cures Blood Disorder in MiceNovember 3, 2016
Scientists from Carnegie Mellon University and Yale University have developed a next-generation gene editing system that has cured a genetic blood disorder in living mice using a simple intra-venous treatment.
The new system uses state-of-the-art peptide nucleic acid (PNA) molecules, a synthetic nucleotide technology that has been pioneered at Carnegie Mellon's Center for Nucleic Acids Science and Technology. It avoids previous issues encountered in other gene editing technologies such as CRISPR, which relies on DNA-cutting enzymes to slice open DNA at a target site to edit a specific gene. The new Carnegie Mellon/Yale system is designed to open up double-stranded DNA and bind near the target site in a highly specific manner without cutting cell's own DNA repair pathways to correct the malfunctioning hemoglobin subunit beta gene.
The new approach can help treat genetic diseases of the blood like beta thalassemia and sickle cell disease.
For more information, read the news release at the Carnegie Mellon University website.
The Crop Biotech Update is a weekly newsletter of ISAAA, a not-for-profit organization. The CBU is distributed for free to over 23,000 subscribers worldwide to inform them about the key developments in biosciences, especially in agricultural biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
News from Around the World
- FAO Report Promotes Biotechnology as Key Tool in Facing Climate Change
- African Party State Delegates Converge for COP/MOP 8 Preparatory Workshop
- Kenyan Editors Urged to Rely on National Biosafety Authority for GMO Safety Matters
- Scientists Trace Evolution of Abscisic Acid
- Non-bruising GE Potato Cleared for Sale by USDA
- Meta-analysis in Mexico Confirms There are No Additional Risks in GM Maize Compared with Conventional Maize
- Scientists Find SGR Gene Induces Color Changes in Leaves
- Philippines Research Shows Bt Eggplant Does Not Harm Non-target Insects
- Research Team Develops Technique that Quickly Identifies Chemicals Affecting Plant Growth
- GM Crops Could Soon be Grown in UK After Brexit, Says Ag Minister
- Overexpression of HvPAPhy_a Gene Increases Phytase Activity in Mature Barley Straw and Grains
- TaCAD12 Gene Contributes to Resistance to Sharp Eyespot Disease in Wheat
Plant Breeding Innovations
- Researchers Review Opportunities Presented by CRISPR-Based Tools in Understanding Plant–Pathogen Interactions
- New Gene Editing Technology Cures Blood Disorder in Mice
- ISAAA Infographic: Approved Transgenic Plant Events
Read the latest:
- Crop Biotech Update (October 5, 2022)
- Genome Editing Supplement (October 5, 2022)
- Gene Drive Supplement (September 28, 2022)
Subscribe to CBU: