Molecular Portrait Reveals Cell Signaling ActivityJuly 29, 2011
Scientists from Stanford University in California headed by Brian Kobilka have finally revealed the structure of of G-protein-coupled receptors (GPCRs), which are involved in biology's most significant signaling mechanisms. After studying this for 20 years they have revealed a three-dimensional atomic structure of an activated GPCR in a complex with its G protein.
GPCRs are located in the cell membranes throughout the human body, where they function as detectors from the external world, waiting for signals like light, odor, and flavor, as well as signals inside the body like hormones and neurotransmitters. Once the signals are recognized, GPCRs activate intracellular G proteins, which then trigger different biochemical pathways.
The structure now explains how G protein's mouth splays wide open when the molecule guanosine diphosphate (GDP) departs. When a GPCR receives a signal, the receptor forces the G protein to throw out the GDP, allowing a molecule of guanosine triphosphate to swoop in and turn on the G protein.
"This is a real breakthrough paper," says biochemist Stephen Sprang at the University of Montana in Missoula. "For a long time, many folks in the field have considered this the hoped-for structure that would ultimately provide a real understanding of how the receptors actually work."
For more details, read the original article at http://www.nature.com/news/2011/110719/full/475273a.html.
See more articles:
News from Around the World
- Strategies to "Freeze the Footprint of Food"
- Kenya Pushes Through GM Cotton Plans
- Africa Needs to Increase S&T Investment
- USDA Reopens Comment Period for Draft EA for Drought Tolerant Corn
- US EPA Approves Syngenta's Dual Modes of Insect Protection with Five Percent Refuge
- Genomics Institute to Offer Remote Data Service
- CSIRO Researchers Develop Crops for the Changing Climate
- Expert Says GM Risk Communication in China Should Be Strengthened
- Reduced Pesticide Poisoning Observed Among Cotton Growers
- Pakistan Needs to Collaborate with China on Agriculture
- Pakistan Seed Board Approves New Seed Varieties
- Gene Discovery in Wild Barley May Lead to Stress Tolerant Crops
- Second Confined GM Field Tests Approved in Miyazaki University
- GM Crops are Essential Innovation in Japanese Agriculture, says JBA President
- GM Drug Trials Starts in UK
- Field Trials Destroyed in Germany
- Andalusian Farmers and Government Officials Want Biotech Crops
- Barley Defense System Against Powdery Mildew
- Scientists Investigate Effect of Rice Sucrose Transporters on Potato Starch Yield
- Over-expression of Plasma Membrane Protein Gene Enhances Cold-resistance in Tobacco
- Researchers Analyze Stress-sensitive Proteins in Broccoli During Post-harvest Aging
Beyond Crop Biotech
- Molecular Portrait Reveals Cell Signaling Activity
- Purdue Biologists Elucidate Bacterial Infection
- Center for Transgenic Mouse Research
- BIO Releases Second Edition of GE Animals Benefits Study
- Asian Food Security Conference in Singapore
- Food and Nutrition in the 21st Century, Warsaw, Poland
- Biotech Country Facts and Trends
- COMSTECH Website
Subscribe to CBU: