Gene Drive Research Makes Exceptional ProgressMarch 30, 2022
University of California San Diego professor Ethan Bier wrote a review on the remarkable progress made in the field of CRISPR-Cas9-based gene-drive systems. The full article is published in Nature Reviews Genetics.
Gene drives can be defined as "selfish genetic elements that are transmitted to progeny at super-Mendelian (>50%) frequencies”. Recently developed CRISPR-Cas9 gene-drive systems have been shown to be efficient in laboratory settings, with the potential to reduce the pervasiveness of vector-borne diseases, crop pests, and non-native invasive species. The highlights of the review article are as follows:
- Gene drive approaches have the potential to deliver anti-malarial effectors or reduce the numbers of disease-transmitting mosquitoes significantly.
- Flexible add-on trailers could update or expand the range of the original drives.
- One of the challenges currently facing the gene drive field is to get regulatory and community approval to test the systems in natural confined environments such as isolated islands.
- Each drive system must design a detailed target–product profile, to be assessed on a case-by-case basis.
Read the review article in Nature Reviews Genetics.
You might also like:
- Gene Drive: The Technology and its Potentials for Biodiversity Conservation
- Guidelines Expanded for Arthropod Gene Drive Research
- Pocket K No. 54: Plant Breeding Innovation: CRISPR-Cas9
Biotech Updates is a weekly newsletter of ISAAA, a not-for-profit organization. It is distributed for free to over 22,000 subscribers worldwide to inform them about the key developments in biosciences, especially in biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
Gene Drive Supplement (March 30, 2022)
- Gene Drive Research Makes Exceptional Progress
- Research Shows Gene Drive Mosquitoes Could Help Malaria Elimination
- Key Insights from Existing Mosquito Control Methods Can Help Guide Gene Drive Technology in the Field
- CRISPR-based Gene Drive Tested in the Diamondback Moth
- Spatial Modeling Used to Analyze Gene Drives for Vertebrate Pest Control
- Study Shows California Residents' Perceptions of Gene Drive Systems to Control Mosquito-Borne Diseases
Read the latest:
- Biotech Updates (March 22, 2023)
- Genome Editing Supplement (March 22, 2023)
- Gene Drive Supplement (February 22, 2023)
Subscribe to BU: