Bt Cry and Cyt Mutants for Overcoming Insect Resistance
June 8, 2012| |
Cry and Cyt proteins from Bacillus thuringiensis (Bt) are used globally to control insect pests, either as insect spray or expressed in Bt crops. A team of scientists from Universidad Nacional Autónoma de México reviewed the constructions of Cry and Cyt anti-toxins to gain information for developing strategies to counter insects' resistance to native Cry and Cyt toxins.
Mario Soberón and colleagues found that the non-toxic helix α-4 mutants of Cry1Ab could oligomerize and interact with native toxin (Cry1AMod) forming inactive hetero-oligomers which blocks the toxicity of native Cry1Ab. On the other hand, the N-terminal domain of Cyt1A containing the helix-bundle also shows a dominant negative phenotype inhibiting native Cyt1Aa toxicity. Based on the results, Cry and Cyt mutants have the potential to be used as anti-toxins in certain environments while Cry1AMod toxins could counter resistance to Cry1A toxin in strains with different mechanisms of resistance.
For more details about the study, visit http://www.sciencedirect.com/science/article/pii/S004835751200065X.
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