Plant-Derived West Nile Infection-Fighting Antibodies as Effective as Conventional Version
February 12, 2010| |
Plant-derived antibodies are as effective as monoclonal antibodies (mAb) developed from mammalian cells at preventing infection and fighting existing infections, according to researchers at the Washington University School of Medicine in St. Louis and Arizona State University. The team of researchers successfully demonstrated the efficacy of Hu-E16 mAb antibodies produced from Nicotiana benthamiana in treating West Nile Virus (WNV) infection in mice. WNV is a virus of the family Flaviviridae and part of the Japanese encephalitis (JE) antigenic complex of viruses. In the United States alone, more than 29,000 human cases have been diagnosed with severe WNV infection during the past decade.
The researchers, reporting in a paper published by PNASΒΈ said that they produced 0.8 g of Hu-E16 per kilogram of fresh Nicotiana benthamiana leaves within 8 days of infiltration. They also showed that a single dose of plant Hu-E16 protected mice against WNV-induced mortality even 4 days after infection at rates that were indistinguishable from mammalian-cell-produced Hu-E16.
Read the paper published by PNAS at http://dx.doi.org/10.1073/pnas.0914503107
| |
Biotech Updates is a weekly newsletter of ISAAA, a not-for-profit organization. It is distributed for free to over 22,000 subscribers worldwide to inform them about the key developments in biosciences, especially in biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
-
See more articles:
-
News from Around the World
- International Potato Center Opens in China
- Uganda Develops a Biotechnology R&D Agenda 2010
- Test Biosafety Proclamation, Says Ethiopia Agriculture Minister
- AFSTA Focuses on the Revitalization of Seed Industry in West Africa
- New Drought Tolerant Maize to Curb Hunger in Africa
- Stakeholder Study on Biotech Perceptions in Egypt
- GM Soybean Receives Go Signal from Brazilian Biosafety Commission
- UA Scientists Study Genetics and Physiology of Soybeans to Increase Dryland Yields
- New GM Events in Colombia
- Peru Now Part of ISAAA Global Biotech Information Network
- Syngenta and IAC Collaborate to Accelerate Sugarcane R&D
- EnviroLogix and Danforth Plant Science Center to Improve Nutrition in Staple Crops
- OGTR Notification for Limited Release of Insect Resistant and Herbicide Tolerant GM Cotton
- Bangladesh PM Bats for Biotechnology
- Economic Implications of Mandatory Labeling Policy in India
- India Puts Moratorium on Bt Brinjal
- Chinese Experts Assure Safety of GM Foods
- European Commission JRC Publishes Two Summary Notifications
- Europe's Farmers Call for Access to GM Crops
- Poland Considers New Law for Cultivation of GM Crops
-
Research Highlights
- Researchers Develop Tomatoes that can Stay Fresh for Over a Month
- Resistant Wheat Plants Stave Off Hessian Flies by Starving Them
- Plant-Derived West Nile Infection-Fighting Antibodies as Effective as Conventional Version
-
Announcements
- Fifth International Meeting on Biotechnology
- Technical Coordinator (Eastern and Southern Africa)
- Funding for Biotech Risk Assessment Research
- Seminar on Impact of EU GMO Regulations on Biotech Research
-
Resources
- USDA Gain Report: The Widespread Use of Biotechnology in Italy
-
Read the latest: - Biotech Updates (April 16, 2025)
- Gene Editing Supplement (April 16, 2025)
- Gene Drive Supplement (February 22, 2023)
-
Subscribe to BU: - Share
- Tweet