Biotech Updates

Study Reveals Key Gene Interaction to Strengthen Grapevine’s Resistance Against Powdery Mildew

December 10, 2025

Researchers from Kunming University of Science and Technology and Northwest A&F University in China have identified a key gene module in grapevine that boosts resistance to Erysiphe necator, the fungal pathogen responsible for powdery mildew. They found that the interaction between two genes, VqMAPK3 and VqERF1B, plays a crucial role in activating defense-related genes that help the plant fight infection.

The study revealed that VqERF1B, a transcription factor from the Chinese wild grape Vitis quinquangularis ‘Danfeng-2,' becomes highly active during infection. Overexpressing this gene in grape leaves increased resistance by elevating the expression of several pathogenesis-related (PR) genes. When VqERF1B was silenced, plants became more susceptible to the disease.

The researchers also discovered that VqMAPK3 directly interacts with VqERF1B, strengthening its ability to regulate PR genes. The findings show that the VqMAPK3-VqERF1B-VqPRs module confers resistance against E. necator in grapevine. This module offers a promising target for developing grapevine varieties with enhanced resistance to powdery mildew.

For more information, read the study from the Journal of Integrative Agriculture.


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