Experts Develop GM Live Vaccine to Protect Cattle from Anaplasma Marginale
November 27, 2024| |
Experts from Kansas State University, the University of Missouri, and Oklahoma State University have developed a genetically modified (GM) live vaccine that protects cattle against virulent Anaplasma marginale infection resulting from infected tick blood feeding.
A. marginale is a known tick-borne bacterial pathogen that causes fever and anemia in cattle. A limited success rate has been reported in killed vaccines derived from infected erythrocytes used to control this disease. In their previous study, the researchers developed a modified live vaccine (MLAV) to induce protective immunity against disease progression.
The current study demonstrated that the immunity from MLAV in cattle prevents the disease progression from virulent A. marginale interstadial transmission from infected Dermacentor variabilis male ticks. The study reported that the nonimmunized control steers developed fever, lethargy, and inappetence several days after tick exposure. In contrast, the MLAV immunized steers remained healthy as compared with the controls.
For more information, read the study from Vaccine.
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