Gene-edited Dairy Goats Exhibit Enhanced Resistance to Mastitis
September 4, 2024 |
Experts from China developed gene-edited dairy goats with enhanced resistance to mastitis through a regulatory sequence gene editing breeding strategy. The results of the study are published in Advance Science.
Mastitis is a common disease affecting the livestock industry worldwide, characterized by the inflammation of the mammary gland. It is one of the leading causes of economic losses in dairy goats resulting from infection caused by pathogens, such as Staphylococcus spp. and Escherichia coli. The researchers proposed the use of gene editing to fight against inflammatory diseases using dairy goats as model animals.
The study successfully developed mastitis-resistant gene-edited goats using the ISDra2-TnpB system. These goats showed increased levels of lysozyme (LYZ) in their mammary glands during E. coli infection, leading to reduced mastitis severity and improved disease resistance. The findings of the study show significant advancements in animal disease resistance breeding.
For more information, read the article from Advanced Science.
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