Scientists Reveal How DNA Repair Mechanism Works
May 29, 2024| |
Researchers from the University of Würzburg have identified how XPD protein examines and handles the repair of DNA damage. Their findings offer the basis for innovative ways to treat different kinds of cancer.
The body of humans has a nucleotide excision repair (NER), which detects damaged DNA and works with other repair proteins to remove and replace defective areas. A central component of NER is the XPD protein that identifies and repairs severe forms of DNA damage, such as interstrand crosslinking that can cause cancer. However, the DNA repair mechanism of the XPD protein was still undetermined.
Würzburg scientists utilized cryo-electron microscopy to study how XPD protein unwinds the DNA double helix to show the damaged areas of interstrand crosslinking. The team then produced a model of how the defective sites are detected and eliminated. Their research may enhance the effectiveness of drugs and help with cancer treatment.
Read the article on Nature Structural & Molecular Biology for more information.
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