Scientists Develop Methods to Validate Gene Regulation NetworksApril 17, 2019
A team of biologists and computer scientists at New York University (NYU) has mapped out a network of interactions for how plant genes coordinate their response to nitrogen, a crucial nutrient and the main component of fertilizer.
The team focused on gene regulatory networks, which consist of transcription factors and the target genes that they regulate. These gene regulatory networks enable organisms to adapt to fluctuating surroundings. However, multi-cellular organisms present a challenge for mapping all connections as the nature of interactions within these complex networks are difficult to experimentally validate using common methods.
Using Arabidopsis, the team combined innovative experimental and computational methods to characterize the gene network underlying nitrogen responses. They scaled-up a cell-based technique that allowed them to experimentally determine more than 85,000 connections between 33 early nitrogen-responsive transcription factors and the target genes they regulate in approximately two months' time. Collectively, the 33 transcription factors regulate 88 percent of the nitrogen response genes in plants. Through the approach they call Network Walking, the scientists could use this vast amount of data to chart a path for a transcription factor from its direct gene targets in root cells to indirect gene targets in plants.
For more details, read the NYU news article.
Biotech Updates is a weekly newsletter of ISAAA, a not-for-profit organization. It is distributed for free to over 22,000 subscribers worldwide to inform them about the key developments in biosciences, especially in biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
News from Around the World
- Scientists Develop Methods to Validate Gene Regulation Networks
- Plants Use Genetic Backup to Protect Stem Cells
- Sex Determination of Papaya Trees Now Possible
- Chinese Scientists' Genome-Edited Wheat to Help Control Weeds
- Pakistan Announces National Coordinated Trials of 85 Bt Cotton Varieties
- China's GM Approval Process Could Cost Farmers Billions
- VIB CRISPR Maize Field Trial Granted Permit
- Vietnamese Scientists Characterize Rice Gene OsSWEET14
- Nematode Resistant Eggplant Developed Through Host-induced Silencing
- HB4 Wheat Compositionally Equivalent to Non-transgenic Wheat
Beyond Crop Biotech
- Tropical Grass Genetic Breakthrough to Help Develop Climate-Friendly Cattle Farms
- National University of Colombia Scientists Gene-Edited Smallest Tomato in the World
- Researchers Characterize Lignin of Rice Mutants Generated Using CRISPR-Cas9
- Scientists Develop DNA- and Marker-free Genome-editing System using Zygotes in Rice
Read the latest:
- Biotech Updates (November 29, 2023)
- Gene Editing Supplement (November 29, 2023)
- Gene Drive Supplement (February 22, 2023)
Subscribe to BU: