Nanobody-mediated Resistance to Grapevine Fanleaf Virus in PlantsOctober 11, 2017
Since their discovery, single-domain, antigen-binding fragments of camelid-derived heavy-chain-only antibodies, also known as nanobodies (Nbs), have been of interest as therapeutics against human diseases and pathogens, including viruses. However, their effect against phytopathogens remains limited.
Caroline Hemmer from the Université de Strasbourg in France aimed to test these nanobodies on the grapevine fanleaf virus (GFLV), the causal agent of fanleaf degenerative disease. The team identified a nanobody specific to GFLV that conferred strong resistance to GFLV upon expression in both tobacco and grapevine, the natural host of the virus. The resistance proved to be effective against a broad range of GFLV isolates. However, the nanobody was useless against GFLV's close relative, Arabis mosaic virus.
These findings could be vital in developing resistance to GFLV in grapevine, as well as the generation of new antiviral strategies in plants based on nanobodies.
For more information, read the article in Plant Biotechnology Journal.
The Crop Biotech Update is a weekly newsletter of ISAAA, a non-for-profit organization. The CBU is distributed for free to over 23,000 subscribers worldwide to inform them about the key developments in biosciences, especially in agricultural biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
News from Around the World
- Four-Step Instructions for Golden Rice Adoption
- GM Soybean Oil Causes Less Obesity and Insulin Resistance
- Scientists Point Out that Africa Needs Technological Transformation in Agri
- U.S. Farmers and Ranchers Alliance Engage Consumers on Biotechnology
- Non-browning Biotech Apples will be Available in the U.S. Soon
- Genetically Improving Nutritional Value of Corn Could Benefit Millions
- ICRISAT Scientists Use Double-defense Biotech Approach to Produce Aflatoxin-free Peanuts
- Study: Food Security Needs More from GM Crops
- Nanobody-mediated Resistance to Grapevine Fanleaf Virus in Plants
Plant Breeding Innovations
- Regulatory Status of Gene-edited Agricultural Products in the EU
- Genome Editing in Potato using TALENs Delivered via Agroinfiltration
Beyond Crop Biotech
- Scientists Induce Resistance to Asthma in Mice
- Cancer Scientists Decode Durian Genome
- Agriculture and Food Security 5th Anniversary Editorial Tackles Biotechnology
- Updated Pocket Ks on Agri-biotech
Subscribe to CBU: