Scientists Induce Resistance to Asthma in MiceOctober 11, 2017
Asthma is a common chronic inflammatory disease in the airways. It was thought to be caused by the combination of environment and genetic factors. Previous studies have suggested that cell immunity played a vital role in regulating the airway hyper reactivity (AHR) and inflammation. Fei Xu of the First Affiliated Hospital of Nanchang University in China developed a mouse model for asthma by expressing the human IL10 and TGFB1 genes to explore the possible interaction between these two during asthma progression.
The transgenic mice exhibited enhanced expression of IL10 and TGFB1. During the ovalbumin challenge, transgenic mice displayed a 1.9-fold higher MCh50 score than wildtype counterparts. Meanwhile, a three-fold decrease of cell counts in bronchoalveolar lavage fluid (BALF) was also recorded. These results suggested that IL10 and TGFB1 cooperatively protected the respiratory system in response to antigenic stimulus.
To study the behaviors of these two genes, the team quantified the expression of downstream genes in both IL10 and TGFB1 signaling. The examined genes in IL10 signaling were significantly repressed, especially IL5. Meanwhile, most genes were not altered in TGFB1 signaling.
These evidences proved that the activation of IL10 and TGFB1 protected the host from ovalbumin-induced asthma, possibly through IL10 signaling. This study shed some light on the modulations these two genes and related networks to asthma progression.
For more on this study, read the article in Transgenic Research.
The Crop Biotech Update is a weekly newsletter of ISAAA, a non-for-profit organization. The CBU is distributed for free to over 23,000 subscribers worldwide to inform them about the key developments in biosciences, especially in agricultural biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
News from Around the World
- Four-Step Instructions for Golden Rice Adoption
- GM Soybean Oil Causes Less Obesity and Insulin Resistance
- Scientists Point Out that Africa Needs Technological Transformation in Agri
- U.S. Farmers and Ranchers Alliance Engage Consumers on Biotechnology
- Non-browning Biotech Apples will be Available in the U.S. Soon
- Genetically Improving Nutritional Value of Corn Could Benefit Millions
- ICRISAT Scientists Use Double-defense Biotech Approach to Produce Aflatoxin-free Peanuts
- Study: Food Security Needs More from GM Crops
- Nanobody-mediated Resistance to Grapevine Fanleaf Virus in Plants
Plant Breeding Innovations
- Regulatory Status of Gene-edited Agricultural Products in the EU
- Genome Editing in Potato using TALENs Delivered via Agroinfiltration
Beyond Crop Biotech
- Scientists Induce Resistance to Asthma in Mice
- Cancer Scientists Decode Durian Genome
- Agriculture and Food Security 5th Anniversary Editorial Tackles Biotechnology
- Updated Pocket Ks on Agri-biotech
Subscribe to CBU: