Researchers Discover MicroRNA that may Protect from Obesity and DiabetesMarch 16, 2016
Obesity is an important factor in the development of diabetes and cardiovascular diseases. While the role of several organs has been implicated in this process, the cell types and factors driving this process have not been clear.
Researchers at Brigham and Women's Hospital (BWH) have discovered that a small, non-coding RNA molecule, miR-181b, is an important determinant of obesity-induced changes by controlling the function of the vessels in adipose tissue.
The team hypothesized that establishing this microRNA in obese mice may improve the development of insulin resistance. Injections of a miR-181b mimic into obese mice improved their insulin sensitivity, glucose levels and reduced inflammation in adipose tissues.
The protein phosphatase PHLPP2 was found as the direct target of miR-181b, and that suppression of the protein improved insulin sensitivity, glucose levels and inflammation in mice. The team also noted that levels of PHLPP2 were higher in diabetic patients than healthy patients, suggesting that findings in mice are relevant to human disease.
For more information, read the article on American Heart Association Journal.
Biotech Updates is a weekly newsletter of ISAAA, a not-for-profit organization. It is distributed for free to over 22,000 subscribers worldwide to inform them about the key developments in biosciences, especially in biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
News from Around the World
- Suppressing Growth: Opposition to GMOs Hurting Developing Nations
- New Study Identifies Sweet Corn Genes for Crowding Tolerance
- Study Suggests Climate Change Impact on Agriculture is Underestimated
- Researchers Discover Gene That Protects against Toxic Byproducts of Photosynthesis
- Scientists Unravel Unknown Receptors and Mechanism for Plant Fertilization
- New EU Project Focuses on Crops Important for Food Security and Bio-Economy
- Ectopic Expression of PtCYP714A3 from Populus trichocarpa Improves Salt Tolerance in Transgenic Rice
- Kn1 Gene Overexpression Improves Transformation Efficiencies of Citrus Cultivars
- OsBBX14 Delays Heading Date in Rice
Beyond Crop Biotech
- Abiotic Stress Tolerance Genes Characterized in Brown Seaweed
- Scientists Develop GM Microbe for Monogastric Animal Nutrition
- Researchers Discover MicroRNA that may Protect from Obesity and Diabetes
- Genome Editing and Gene Modulation Congress 2016
- 3rd Plant Genomics Congress: Asia
- 5th International Conference and Exhibition on Metabolomics
Read the latest:
- Biotech Updates (November 29, 2023)
- Gene Editing Supplement (November 29, 2023)
- Gene Drive Supplement (February 22, 2023)
Subscribe to BU: