Biotech Updates

New Method for Dev't of Altered Mice to Model Human Disease

May 15, 2013

Scientists at the Whitehead Institute for Biomedical Research in Massachusetts, U.S., devised a new method in developing genetically engineered mice to be used for modelling human diseases. The conventional method would take three to four years of development while the new method can now make a GE mouse in just three to four weeks. Aside from the shortened length of time for development, the new method is generally less complicated and more efficient than the conventional way. Thus, the innovators are expecting that other laboratories can easily adopt the new method.

The scientists create models in mice by transforming certain genes that have been known to be associated with a given disease. Through the new method known as CRISPR (for "clustered regularly interspaced short palindromic repeat")/Cas (for "CRISPR-associated"), multiple genes can be altered in a single multicellular organism.

Read the research article at