Experts Develop PiggyBac for Delivery of CRISPR Tools into Stem CellsMarch 23, 2022
A group of experts from Pennsylvania State University and partners developed a technique that enhances the lifespan and efficiency of CRISPR gene-editing tools after delivery into stem cells. Bioactive Materials published their findings.
Stem cells are used by researchers to investigate the impact of disease on various tissue types due to their pluripotency or the ability to produce cells of any time. However, the delivery of gene-editing tools into stem cells can be inefficient, time-consuming, or expensive. Thus, the research team designed a delivery system using an enzyme that would allow for long-term integration of gene-editing tools.
Through conventional methods, the DNA components that transport tools into cells can last up to three days before being destroyed. With the enzyme in the system called PiggyBac, there will be permanent establishment of the editing tools into the cell's genetic code. The system was tested in human embryonic stem cells and it was shown that PiggyBac successfully and permanently integrated the gene editing tools into the cell's genome.
You might also like:
- Pocket K No. 54: Plant Breeding Innovation: CRISPR-Cas9
- Scientist Introduces CRISPR 3.0 System for Highly Efficient Gene Activation in Plants
- Plants Use Genetic Backup to Protect Stem Cells
The Crop Biotech Update is a weekly newsletter of ISAAA, a not-for-profit organization. The CBU is distributed for free to over 23,000 subscribers worldwide to inform them about the key developments in biosciences, especially in agricultural biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
Research and Tools
- Spineless Fish Developed Through Genome Editing in China
- Physical Model Maps Cas9 Cutting Behavior
- Experts Develop PiggyBac for Delivery of CRISPR Tools into Stem Cells
Policy Considerations and Approvals
- Swiss Parliament Eases Restriction for Gene Editing
- NIAB Lauds UK Parliamentary Approval of New Gene Editing Rules
Trends and Impact
- Genome Editing Can Help Achieve UN Sustainable Development Goals
Read the latest:
- Crop Biotech Update (January 25, 2023)
- Genome Editing Supplement (January 18, 2023)
- Gene Drive Supplement (January 25, 2023)
Subscribe to CBU: