GM Tobacco Expressing Aprotinin
February 8, 2008| |
Aprotinin is a natural serine protease inhibitor used in medical procedures to lower inflammatory response and reduce blood loss associated with cardiac and liver surgery. This compound is also significant in preventing degradation of protein products in research and manufacturing processes and has been administered as a treatment for acute pancreatitis. Aprotinin was first identified in bovine lungs, but can also be obtained from recombinant yeasts.
Scientists from Bayer Bioscience in Belgium have developed transgenic tobacco plants expressing elevated levels of aprotinin. The recombinant protease inhibitor was specifically secreted in the chloroplast lumen (a specialized membrane bound compartment). The aprotinin obtained by the scientists was found to be biologically active, requiring minimal alteration before use.
The abstract of the paper published by Plant Biotechnology Journal is available at http://www.blackwell-synergy.com/doi/abs/10.1111/j.1467-7652.2008.00321.x
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