GM Pigs Resist Infection from Classical Swine Fever Virus
December 19, 2018| |
Researchers have developed genetically modified (GM) pigs that are resistant to the classical swine fever virus (CSFV), a widespread, highly contagious, often fatal disease that causes significant economic losses. The study, led by Hongsheng Ouyang and colleagues from Jilin University, is published in the open-access journal PLOS Pathogens.
The researchers investigated the biology of CSFV extensively, as there is an urgent need to develop effective approaches to eradicate CSFV. Ouyang and colleagues generated CSFV-resistant pigs by combining the gene-editing tool CRISPR-Cas9 with RNA interference (RNAi), a technique that silences gene expression.
The researchers showed that the GM pigs could effectively limit the replication of CSFV and reduce CSFV-associated clinical signs and mortality. Disease resistance could also be stably transmitted to first-generation offspring. Currently, the researchers are conducting long-term studies to monitor the safety and effectiveness of this approach as these animals age.
For more details, read the open access paper in PLOS Pathogens.
| |
Biotech Updates is a weekly newsletter of ISAAA, a not-for-profit organization. It is distributed for free to over 22,000 subscribers worldwide to inform them about the key developments in biosciences, especially in biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
-
See more articles:
-
News from Around the World
- Multidisciplinary Study Traces Movement of Maize in South America
- Rwandan Women in Biosciences Embrace Science Communication
- Iowa State University Study Says Anti-GMO Sentiment Has Repercussions for Developing World
- Scientists Discover Way to Make Rice Plants Replicate through Seeds as Clones
- Australian OGTR Receives License Application for Field Trial of GM Chickpea
- Japan May Allow Genome-edited Food Sale
- Plants Don't Like to be Touched, Study Finds
- Stockholm University Scientists Discover Gene that Helps Submerged Plants
-
Research Highlights
- Research Reveals MON 810 and NK603 GM Maize Have No Effects on Rat Health or Metabolism
- Study Shows Inheritance of Transgenes in Bt Cotton Lines Resistant to Bollworm
-
Beyond Crop Biotech
- GM Pigs Resist Infection from Classical Swine Fever Virus
-
Resources
- Revised ISAAA Infographics: 22 Years of Biotech Crops in the World
- Talking Biotech: How Do We Get Consumers to Think Like Scientists?
-
Plant
- Europe Grants CRISPR-Cas9 Patent to Calyxt
- CRISPR-Cas9 Used in Breeding Indica Glutinous CMS Line WX209A
-
Read the latest: - Biotech Updates (September 11, 2024)
- Gene Editing Supplement (September 11, 2024)
- Gene Drive Supplement (February 22, 2023)
-
Subscribe to BU: - Share
- Tweet