Researchers Reveal Key Zika Virus Protein Structure

Researchers led by the University of Michigan and Purdue University have revealed the molecular structure of a protein produced by the Zika virus thought to be involved in its reproduction and interaction with a host's immune system.

The NS1 protein of Zika has substantially different electrical-charge properties than those of other flaviviruses. The study was also the first to capture the molecular structure of flexible loops on the wing domains of the protein, which were not seen in previous studies. It was previously thought this loop flipped up, but the new study showed it flips down from the wings.

"Seeing this difference provides new insights that help us better understand the NS1 protein," said Richard Kuhn, Purdue University professor, and member of the research team that first determined the structure of the Zika virus. "Understanding its structure and functions help us identify targets for inhibitors to block important viral processes and treat infection," he added.

For more information, read the news release at the University of Michigan website.