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Crop Biotech Update

Rice Gene OsSRT1 Regulates Starch Metabolism during Seed Development

June 1, 2016

The rice gene OsSRT1 is closely related to the human SIRT6 gene, which plays key roles in genome stability and metabolic homeostasis. Researchers from Huazhong Agricultural University in China, led by Hua Zhang, investigated the role of OsSRT1 in rice seed development.

Down-regulation of OsSRT1 induced expression of Rice Starch Regulator1 (RSR1) and amylases genes in developing seeds. This resulted in a decrease of starch synthesis and an increase of starch degradation, leading to abnormal seed development. Further analysis revealed that OsSRT1 was required to reduce histone H3K9 acetylation on starch metabolism genes as well as transposons in developing seeds. Moreover, OsSRT1 was found to directly bind to starch metabolism.

Results showed that OsSRT1-mediated histone deacetylation is involved in starch accumulation and transposon repression to regulate normal seed development.

For more on the study, read the article in Plant Science.