Scientists Map Loops in Human Genome
January 7, 2015| |
Scientists from Harvard University, Baylor College of Medicine, Rice University, and the Broad Institute of MIT and Harvard, have assembled the first high-resolution, three dimensional maps of entire folded genome which provides a structural basis for gene regulation. This "genomic origami" allows the same genome to produce different types of cells.
The researchers used a technology known as "in situ Hi-C" to collect billions of bits of DNA which were analyzed for signs of loops. Loops form when two distant bits of DNA in the genome sequence end up in close contact in the folded version of the genome in a cell's nucleus. The researchers found that loops and other genome folding patterns are vital in genetic regulation.
The research is published at http://www.seas.harvard.edu/news/2014/12/scientists-map-human-loop-ome (news release) and http://www.cell.com/abstract/S0092-8674(14)01497-4 (video abstract).
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