Cbl Gene Product in Transgenic Tobacco Does Not Cause Allergies
August 20, 2014| |
Recently, the Calcineurin B-like (cbl) gene was inserted in tobacco (Nicotiana tabbacum) to render it salt tolerant. A team led by Premendra Dwivedi of CSIR-Indian Institute of Toxicology Research assessed the allergenic potential of the cbl gene product and compared its effects to wild-types (WT).
Analysis revealed no significant similarities between the CBL protein and known allergens. Moreover, there was no difference found between the proteins of the GM and WT tobacco. Rapid digestion of the CBL protein also indicated reduced chances of the protein to induce allergenicity. In addition, mice injected with WT and GM tobacco proteins showed comparable levels of clinical score and histamine levels. These findings suggest that the cbl gene inserted in tobacco will not cause any allergic risk to consumers.
To learn more on this allergenic potential assessment study, feel free to visit: http://link.springer.com/article/10.1007/s11130-014-0435-8/fulltext.html
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