Species: Goat (Capra hircus)

Country of 1st Author: China
Year: 2015

Institute	Northwest A&F University Yangling 712100, Shaanxi CN
Editing Method	Embryo edit
SDN Type	SDN-1
Delivery	by coinjection of one-cell stage embryos with Cas9 mRNA and sgRNAs targeting two functional genes (MSTN and FGF5), we successfully produced gene-modified goats with either one or both genes disrupted
Foreign DNA	No
Undergone Regulatory Process	No

Target Gene(s)

Gene Name	Gene Trait	Trait Category	NGT	Methods/Remarks
FGF5 Fibroblast Growth Factor 5	Increased fiber length	Yield	CRISPR Cas9 (spCas9)
MSTN Myostatin	Double muscle	Yield	CRISPR Cas9 (spCas9)

References, Documents, and Links

• Generation of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system