Species: Silkworm (Bombyx mori)

Country of 1st Author: China
Year: 2018

Institute	Chinese Academy of Sciences, Shanghai CN
Editing Method	Other
SDN Type	SDN-3
Delivery	Germ line transformation was performed by delivering mixed solutions of TALEN mRNAs and donor plasmids into preblastoderm embryos of B. mori.
Foreign DNA	Yes
Undergone Regulatory Process	No

Target Gene(s)

Gene Name	Gene Trait	Trait Category	NGT	Methods/Remarks
MaSp1 major ampullate spidroin-1	Spider silk production in silk worm	Quality	TALEN	using transcription activator-like effector nuclease-mediated homology-directed repair to replace the silkworm fibroin heavy chain gene (FibH) with the major ampullate spidroin-1 gene (MaSp1)in the spider Nephila clavipes.

References, Documents, and Links

• Mass spider silk production through targeted gene replacement in Bombyx mori