Anti-Allergy GM Rice Appears Safe in Animal StudiesJune 26, 2009
A team of researchers from Japan's National Institute for Agrobiological Sciences has successfully developed a genetically modified rice variety that fights Japanese cedar pollen allergy. What's more, they were able to demonstrate that oral administration of the GM rice is safe. Japanese cedar pollen allergy is an important public health problem in Japan, affecting millions of Japanese from February to April each year.
Fumio Takaiwa and colleagues developed a transgenic rice variety accumulating a hybrid peptide of major human T-cell epitopes (7Crp) from Japanese cedar pollen allergens. 7Crp is an ideal safe tolerogen, since it possesses the same level of immunogenicity as the native allergens without binding to allergen-specific immunoglobulin E.
The researchers fed a steamed version of the transgenic rice and a non-transgenic version to a group of monkeys (crab-eating macaques, Macaca fascicularis) everyday for 26 weeks. At the end of the study period, the test animals did not show any health problems. According to the researchers, this demonstrates that the allergy-fighting rice is safe for consumption. The macaques were monitored for clinical signs, body weight, necropsy findings, histopathological findings, hematological data, blood biochemical data, and urinalysis.
The paper published by the Journal of Food and Agricultural Chemistry is available at http://dx.doi.org/10.1021/jf900371u
The Crop Biotech Update is a weekly newsletter of ISAAA, a non-for-profit organization. The CBU is distributed for free to over 23,000 subscribers worldwide to inform them about the key developments in biosciences, especially in agricultural biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
News from Around the World
- Clinton: 7 Principles for Sustainable Agricultural Systems Worldwide
- GM Maize for Local Trials by 2010
- OFAB Launched in Tanzania
- Arabic Book on Biotechnology in Egypt
- Regional Program on Biosafety Launched in West Africa
- Egyptian Agriculture Extension Workers Learned Biotechnology
- Scientists Identify Compound that Kills Mycotoxin-Producing Pathogen
- Arabidopsis Genome Gets an Overhaul
- Scientists Decipher Genome of Nitrogen-Fixing Bacterium
- Monsanto to Commercialize First Biotech Insect-Protected Soybean in Brazil
- Monsanto, Dole to Collaborate on Veggie Breeding
- Malaysia Moves Toward Setting Up a National Bioethics Committee
- Biofuel Impact on Food Crops in Thailand
- Australia Approves GM Blue Rose
- Malaysian Biotech Human Capital Development Report
- DuPont Makes Cotton Acquisitions in India
- New Serbian Law Prohibits Commercial Growing, Trade of GMOs
- German Court Sentences Anti-GMO Activists for Destroying Wheat Field
- Researchers Modify Castor Oil Plants to Produce Bio-lubricants
- Green Biotechnology and Climate Change
- French Scientists: Germany’s GM Maize Ban Unfounded
- Anti-Allergy GM Rice Appears Safe in Animal Studies
- ISAAA Video on "Knowledge, Technology and Poverty Alleviation" Available in 17 Languages"
- Call for John Dillon Memorial Fellowship
- Book on Biosafety Regulations in the Philippines
- Traditional and Alternative Medicine: Research and Policy Perspective
Subscribe to CBU: