Biotech Updates

Maturation of N-Glycosylated Proteins is Required for Salinity Tolerance

April 18, 2008

The proteins produced after translation are packaged in the cell’s endoplasmic reticulum and Golgi apparatus. Polysaccharide chains are attached to target proteins through a process called glycosylation. “Coating” proteins with sugar serves several functions. Some proteins do not fold correctly unless they are first glycosylated. Glycosylation also confers stability to proteins. The N-glycosylation pathway in the endoplasmic reticulum has been shown to regulate protein quality control and cell wall synthesis in plants. An international team of scientists now reports that maturation of N-glycosylated proteins in the Golgi apparatus is required for salt tolerance in the model plant Arabidopsis. The researchers conducted a systematic salt tolerance analysis of protein N-glycosylation pathway mutants. Mutants with defective N-glycan modification exhibited extreme sensitivity to salt stress, as shown by growth inhibition and aberrant root-tip morphology.

The abstract of the paper published by PNAS is available at