Novel Method for Efficient Transport of Large Genes
October 25, 2023| |
Researchers from various institutions developed REVeRT, which is a novel approach to transporting large genes. This method demonstrates great potential for therapeutic applications.
Adeno-associated viral (AAV) vectors are commonly used in gene editing and therapy to transport genetic material. However, AAVs cannot transport large genes because they have limited DNA uptake capacity. To address this issue, the research team developed REVeRT, which is a dual AAV vector technology that is based on reconstitution via mRNA trans-splicing.
"The advantages of this method are increased efficiency and fewer side effects. It is also more flexible than previous methods, as the large genes can be divided into two fragments at various points," explains Elvir Becirovic, one of the authors of the study.
For more information, read the journal article on Nature Communications.
| |
You might also like:
- Smaller and More Efficient CRISPR-Based Tool
- Researchers Develop Method that can Modify Individual Animal Cell Differently
- Gene Therapy Treats Rare Brain Disorder in Mice
Biotech Updates is a weekly newsletter of ISAAA, a not-for-profit organization. It is distributed for free to over 22,000 subscribers worldwide to inform them about the key developments in biosciences, especially in biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
-
See more articles:
-
Plant
- Chinese Academy of Sciences Scientists Clone Gene Responsible for Glufosinate Resistance in Rice
- GM Orchids Exhibit Water-efficient Photosynthesis
- IRRI Scientists Discover Genes for Low and Ultra-low Glycemic Index Rice
- China Takes a Step Closer to Boosting Production of GM Corn and Soybean
-
Health
- Novel Method for Efficient Transport of Large Genes
-
Environment
- Researchers Develop Artificial Protein That Can Degrade Microplastics
-
Read the latest: - Biotech Updates (May 15, 2024)
- Gene Editing Supplement (May 15, 2024)
- Gene Drive Supplement (February 22, 2023)
-
Subscribe to BU: - Share
- Tweet