Novel Method for Efficient Transport of Large Genes
October 25, 2023| |
Researchers from various institutions developed REVeRT, which is a novel approach to transporting large genes. This method demonstrates great potential for therapeutic applications.
Adeno-associated viral (AAV) vectors are commonly used in gene editing and therapy to transport genetic material. However, AAVs cannot transport large genes because they have limited DNA uptake capacity. To address this issue, the research team developed REVeRT, which is a dual AAV vector technology that is based on reconstitution via mRNA trans-splicing.
"The advantages of this method are increased efficiency and fewer side effects. It is also more flexible than previous methods, as the large genes can be divided into two fragments at various points," explains Elvir Becirovic, one of the authors of the study.
For more information, read the journal article on Nature Communications.
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