New Method Produces GM Measles Virus Using Only Two ComponentsDecember 7, 2022
A team of researchers from the Paul Erlich Institute in Germany was able to develop a two-component measles virus rescue system that has all the elements ready in the required proportions. Their study is expected to create opportunities for better recombinant measles virus production for research and development.
Genetically modified (GM) measles virus has been used to design viral vector vaccine candidates for protection against other viruses and cancer treatment. But producing it is complex and sometimes inefficient. Using the new method, the German scientists made modified virus genomes on plasmid DNA that multiply autonomously in harmless bacteria. It involves only two components: the plasmid that codes for the modified viral genome and the helper plasmid that bundles all the required helper functions.
The new method works when each component's expression strength adapts to the necessary conditions by coordinated use of the promoters. The sophisticated control is what makes it possible to produce recombinant measles virus based on only two plasmids.
This development makes measles virus research more promising. Further studies were recommended to attain an efficiency of the more complex methods currently being used in virus research.
More information is available in the Journal of General Virology and a news release by Medical Express.
You might also like:
- CRISPR Helped to Successfully Prevent and Treat COVID-19 Infections
- Scientists Develop Cow's Milk against HIV
- Protein Interaction In HIV Treatment
Biotech Updates is a weekly newsletter of ISAAA, a not-for-profit organization. It is distributed for free to over 22,000 subscribers worldwide to inform them about the key developments in biosciences, especially in biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
News from Around the World
- Global Leaders Tackle Conservation at UN Biodiversity Conference
- ARS Introduces Improved Winter Peas for Food Use
- CIMMYT Study Says Breeding New Crops Must Adapt to Climate Change
- Researchers Identify Genes to Help Fruit Adapt to Droughts
- Australia's Gene Regulator OGTR Invites Comments on Field Trial of GM Perennial Ryegrass
- Science Communication Expert Hailed as One of the Filipino Faces of Biotechnology
- New Method Produces GM Measles Virus Using Only Two Components
- Climate Resilience Linked to Lignin Chemistry in Plants
Read the latest:
- Biotech Updates (March 22, 2023)
- Genome Editing Supplement (March 22, 2023)
- Gene Drive Supplement (February 22, 2023)
Subscribe to BU: