CRISPR Gene Editing Stops COVID-19 from Replicating in Infected Human CellsJuly 21, 2021
In a major step towards a new treatment for COVID-19 and future pandemic viruses, scientists at The Peter MacCallum Cancer Centre (Peter Mac) and The Peter Doherty Institute for Infection and Immunity (Doherty Institute) in Australia have found a way to stop the SARS-CoV-2 virus from replicating in infected human cells.
This breakthrough comes from a 2019 Peter Mac research by Dr. Mohamed Fareh and Professor Joe Trapani who showed that the CRISPR gene editing tool could be used to eliminate abnormal RNAs that drive children's cancers. Together with Director Doherty Institute Professor Sharon Lewin and Dr. Wei Zhao, the same approach has been shown to suppress replication of the RNA virus SARS-CoV-2 and its variants in a test tube model. The research team used CRISPR-Cas13b which binds to target RNAs and degrades part of the virus' genome needed to replicate inside cells. The collaborating team will now move to test this approach in animal studies and eventually a clinical trial.
According to Professor Lewin, the pandemic response was focused on rolling out protective vaccines but the need for treatments specific to COVID-19 patients remains urgent. Dr. Fareh said there were signs this approach could also be applied to a host of existing viruses and be a game-changer for how they are currently treated.
For more details, read the article on the Peter Mac website.
You might also like:
- Experts Release Guidance on How to Communicate about COVID-19 Vaccine Efficacy
- Unraveling Coronavirus Structure for Effective Vaccine and Medication
- Pocket K No. 58: COVID-19 Treatment Efforts Using Plant Technologies
The Crop Biotech Update is a weekly newsletter of ISAAA, a non-for-profit organization. The CBU is distributed for free to over 23,000 subscribers worldwide to inform them about the key developments in biosciences, especially in agricultural biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
- Initial Trials of Nasal Spray Vaccine for COVID-19 and Flu Show Positive Results
- CRISPR Gene Editing Stops COVID-19 from Replicating in Infected Human Cells
News from Around the World
- Bias-language Study About GM Crops Reveals Positive Stance About Genetic Modification
- Regulatory and Governance Considerations for Gene Drive Research
- Nitrogen Use Efficient Rice Getting Closer to Farmers' Fields in Nigeria
- Wild Sorghum Offers Toolbox for Climate-Proof Crops
- USDA APHIS Proposes Exemption of Gene Modifications Similar to Conventional Breeding from Biotech Regulations
- Australian Researchers Develop Tools to Identify Plant Genes Resistant to Disease-causing Fungi
- Wageningen Scientists Unravel Onion Genome
Plant Breeding Innovations
- Chinese Scientists Predict Bright Future for Genome Edited Oil Crops
- Nitrogen Use Efficient Wheat Developed Using CRISPR-Cas9
- Remodeling the Gene Editing Regulatory Landscape Necessary, Report
Subscribe to CBU: