Mexican Researchers Enhance Lipid Production in YeastJanuary 31, 2018
Yarrowia lipolytica is a common biotechnological platform for the production of lipids, the preferred feedstock for the production of biofuels and chemicals. To reduce the cost of microbial lipid production, inexpensive carbon sources should be used, such as lignocellulosic hydrolysates. Unfortunately, lignocellulosic materials often contain toxic compounds and a large amount of xylose, which cannot be used by the yeast.
The team of Xochitl Niehus from the Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco in Mexico engineered the yeast to use xylose as a carbon source for the production of lipids. The team achieved this by overexpressing native genes of Y. lipolytica.
The lipid content was further increased in the yeast by overexpressing the inserted genes involved in the production of lipid precursors from xylose in Y. lipolytica. The engineered strains were able to produce high yields of lipids on a xylose-rich agave bagasse hydrolysate inspite of the presence of toxic compounds.
This study shows the potential of metabolic engineering in reducing costs by allowing lipid production from inexpensive feedstock.
Biotech Updates is a weekly newsletter of ISAAA, a not-for-profit organization. It is distributed for free to over 22,000 subscribers worldwide to inform them about the key developments in biosciences, especially in biotechnology. Your support will help us in our mission to feed the world with knowledge. You can help by donating as little as $10.
See more articles:
News from Around the World
- Hunger in Conflict Areas Continues to Escalate
- Namibia Launches First GM Detection Lab
- African Women Vow to Rally Behind Biotech
- Scientists Explain How A Protein Helps Plants "Muscle Up" Bacteria in the Cold
- Arctic® Fuji Apple Gets Canadian Approval
- Importance of IP and Its Application to Biotech Emphasized
- Gene Editing and Genomics Discussed at UP Los Baños Seminar
- "Wild" Genes Open Up Opportunities for Better Rice Varieties
- UZH Scientists Develop Wheat Lines Resistant to Powdery Mildew
- Researchers Identify Plum Pox Virus Susceptibility Genes in Apricot
- Walnut Gene Involved in Cadmium Stress Response
Beyond Crop Biotech
- Non-coding DNA Vital for Brain Development
- Australian OGTR Invites Comments for Field Trial of GM Buffalo Grass
- 10th World Potato Congress
- Researchers Perform Allele Exchange at EPSPS Locus in Cassava using CRISPR-Cas9
Read the latest:
- Biotech Updates (March 22, 2023)
- Genome Editing Supplement (March 22, 2023)
- Gene Drive Supplement (February 22, 2023)
Subscribe to BU: