Species: Chicken (Gallus gallus)

Country of 1st Author: Australia
Year: 2021

Institute	CSIRO Health and Biosecurity, Australian Centre for Disease Preparedness AU
Editing Method	Other
SDN Type	SDN-3
Delivery	Tol2 transposon constructs encoding Cas9 and guide RNAs (gRNAs) specific to the immediate early infected-cell polypeptide-4 (ICP4) of MDV.
Foreign DNA	Yes
Undergone Regulatory Process	No

Target Gene(s)

Gene Name	Gene Trait	Trait Category	NGT	Methods/Remarks
ICP4 immediate early infected-cell polypeptide-4	Resistance against Marek's disease	Biotic Stress	CRISPR Cas9 (spCas9)

References, Documents, and Links

• In Vivo Inhibition of Marek's Disease Virus in Transgenic Chickens Expressing Cas9 and gRNA against ICP4