Yale University Introduces Cas12a-Based Method for Dual Gene Activation and Knockout
March 26, 2025| |
Harnessing the power of CRISPR-Cas12a technology, Yale University researchers developed a novel system for dual-gene activation and knockout (DAKO). This new system allows a single treatment to cause two events at the same time- the activation of one gene and the suppression of another.
DAKO uses Cas19a and can be as precise as Cas9, with the additional benefit of performing multiple edits at once. Thus, it is an ideal system to develop a new biological model for testing various hypotheses. With DAKO gene editing, it is now possible to boost both the desired activity beyond normal levels and remove the system that would inhibit this desired effect. DAKO system could revolutionize treatments, especially in oncology, neurology, and metabolic therapies.
Read more from Nature and Securities IO.
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