More Precise Timing of Gene Editing Achieved with Chemical Method

Nature Communications reported a technique that combines gene editing tool CRISPR with a chemical process. This technique allows gene editing to be more precisely located and timed while reducing potential side effects.

Case Western Reserve scientists focused on controlling RNA, which can have several changes with similar genetic sequences but varied characteristics and roles. They were able to control the precise location and timing of changes to the RNA by combining CRISPR with their chemical process involving abscisic acid (ABA), a common plant hormone. The process called “chemically induced proximity” allowed the researchers to write or erase a particular structural component in the RNA known as m6A. Through this method, they could switch between two versions of the RNA. They believe that m6a modification regulates important RNA processes and properties, and is also involved in several human diseases.

The findings could lead to more effective treatments, including those for cancers.

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